Adiponectin and Cardiovascular Disease

被引：173

作者：

Shibata, Rei ^{[1
]}

Ouchi, Noriyuki ^{[2
]}

Murohara, Toyoaki

机构：

[1] Nagoya Univ, Dept Cardiol, Grad Sch Med, Showa Ku, Nagoya, Aichi 4668550, Japan

[2] Boston Univ, Sch Med, Mol Cardiol Whitaker Cardiovasc Inst, Boston, MA 02118 USA

来源：

CIRCULATION JOURNAL | 2009年 / 73卷 / 04期

关键词：

Adiponectin; Cardiovascular disease; Obesity; CORONARY-HEART-DISEASE; ACTIVATED PROTEIN-KINASE; VENTRICULAR DIASTOLIC FUNCTION; ISCHEMIA-REPERFUSION INJURY; IMPAIRED GLUCOSE-TOLERANCE; ADIPOSE-SPECIFIC PROTEIN; MOLECULAR-WEIGHT FORM; BODY-MASS INDEX; INSULIN-RESISTANCE; PLASMA ADIPONECTIN;

D O I：

10.1253/circj.CJ-09-0057

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Obesity is strongly associated with metabolic and cardiovascular disorders. Adiponectin is an adipose-derived plasma protein that is downregulated in subjects with obesity-related disorders. Low levels of adiponectin are associated with the increased prevalence of obesity-linked cardiovascular diseases, including ischemic heart disease and peripheral artery disease. Experimental findings have shown that adiponectin has beneficial effects in the cardiovascular system by directly acting on the component cells of the heart and blood vessels. Adiponectin protects cardiovascular tissues under conditions of stress through a number of mechanisms: inhibition of pro-inflammatory and hypertrophic responses, and stimulation of endothelial cell responses. These effects of adiponectin are mainly attributed to the modulation of signaling molecules, including AMP-activated protein kinase. Thus, adiponectin could be a promising therapeutic target for cardiovascular diseases. (Circ J 2009;73: 608-614)

引用

页码：608 / 614

页数：7

共 97 条

[41] Adipokines as emerging mediators of immune response and inflammation [J].

Lago, Francisca ;

Dieguez, Carlos ;

Gomez-Reino, Juan ;

Gualillo, Oreste .

NATURE CLINICAL PRACTICE RHEUMATOLOGY, 2007, 3 (12) :716-724

[42] Plasma adiponectin levels are associated with insulin resistance, but do not predict future risk of coronary heart disease in women [J].

Lawlor, DA ;

Smith, GD ;

Ebrahim, S ;

Thompson, C ;

Sattar, N .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (10) :5677-5683

[43] Exacerbation of heart failure in adiponectin-deficient mice due to impaired regulation of AMPK and glucose metabolism [J].

Liao, YL ;

Takashima, S ;

Maeda, N ;

Ouchi, N ;

Komamura, K ;

Shimomura, I ;

Hori, M ;

Matsuzawa, Y ;

Funahashi, T ;

Kitakaze, M .

CARDIOVASCULAR RESEARCH, 2005, 67 (04) :705-713

[44] Adiponectin resistance exacerbates insulin resistance in insulin receptor transgenic/knockout mice [J].

Lin, Hua V. ;

Kim, Ja-Young ;

Pocai, Alessandro ;

Rossetti, Luciano ;

Shapiro, Lawrence ;

Scherer, Philipp E. ;

Accili, Domenico .

DIABETES, 2007, 56 (08) :1969-1976

[45] Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus - A meta-analysis of randomized trials [J].

Lincoff, A. Michael ;

Wolski, Kathy ;

Nicholls, Stephen J. ;

Nissen, Steven E. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2007, 298 (10) :1180-1188

[46] Adiponectin and coronary heart disease: The Strong Heart Study [J].

Lindsay, RS ;

Resnick, HE ;

Zhu, JH ;

Tun, ML ;

Howard, BV ;

Zhang, Y ;

Yeh, JL ;

Best, LG .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2005, 25 (03) :E15-E16

[47] Adiponectin and development of type 2 diabetes in the Pima Indian population [J].

Lindsay, RS ;

Funahashi, T ;

Hanson, RL ;

Matsuzawa, Y ;

Tanaka, S ;

Tataranni, PA ;

Knowler, WC ;

Krakoff, J .

LANCET, 2002, 360 (9326) :57-58

[48] CDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (Adipose most abundant gene transcript 1) [J].

Maeda, K ;

Okubo, K ;

Shimomura, I ;

Funahashi, T ;

Matsuzawa, Y ;

Matsubara, K .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 221 (02) :286-289

[49] Increase in serum adiponectin concentration in patients with heart failure and cachexia: relationship with leptin, other cytokines, and B-type natriuretic peptide [J].

McEntegart, Margaret B. ;

Awede, Bonaventure ;

Petrie, Mark C. ;

Sattar, Naveed ;

Dunn, Francis G. ;

MacFarlane, Niall G. ;

McMurray, John J. V. .

EUROPEAN HEART JOURNAL, 2007, 28 (07) :829-835

[50] Adiponectin level and left ventricular hypertrophy in Japanese men [J].

Mitsuhashi, Hirotsugu ;

Yatsuya, Hiroshi ;

Tamakoshi, Koji ;

Matsushita, Kunihiro ;

Otsuka, Rei ;

Wada, Keiko ;

Sugiura, Kaichiro ;

Takefuji, Seiko ;

Hotta, Yo ;

Kondo, Takahisa ;

Murohara, Toyoaki ;

Toyoshima, Hideaki .

HYPERTENSION, 2007, 49 (06) :1448-1454

← 1 2 3 4 5 6 7 8 9 10 →