Ocular pigmentation associated with clozapine

被引:17
作者
Borovik, Armand M. [1 ]
Bosch, Martina M.
Watson, Stephanie L. [1 ]
机构
[1] Prince Wales Hosp, Dept Ophthalmol, Sydney, NSW, Australia
关键词
CHLORPROMAZINE THERAPY; DRUGS;
D O I
10.5694/j.1326-5377.2009.tb02353.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A 55-year-old woman who was treated with long-term, high-dose clozapine for schizophrenia presented with bilateral decreased visual acuity. She had pigmentary changes affecting the cornea and the retina, as well as stellate cataract. Chlorpromazine use is known to produce similar changes, but this is the first report to our knowledge of pigmentation associated with clozapine use. (MJA 2009, 190: 210-211)
引用
收藏
页码:210 / 211
页数:2
相关论文
共 10 条
[1]  
BOCK E, 1963, AM J OPHTHALMOL, V56, P808
[2]  
COHEN J, 1981, J PHARMACOL EXP THER, V218, P390
[3]  
DELUISE VP, 1981, ANN OPHTHALMOL, V13, P953
[4]  
GREINER AC, 1964, CAN MED ASSOC J, V90, P663
[5]  
Lal S, 2000, J PSYCHIATR NEUROSCI, V25, P281
[6]   Effects of chronic lithium treatment on retinal electrophysiologic function [J].
Lam, RW ;
Allain, S ;
Sullivan, K ;
Beattie, CW ;
Remick, RA ;
Zis, AP .
BIOLOGICAL PSYCHIATRY, 1997, 41 (06) :737-742
[7]  
*NOV PHARM AUSTR P, 2007, CLOZARIL CLOZAP 0323
[8]   OCULAR COMPLICATIONS OF CHLORPROMAZINE THERAPY [J].
PETROHELOS, MA ;
TRICOULIS, D .
OPHTHALMOLOGICA, 1969, 159 (1-3) :31-+
[9]   In vivo confocal microstructural analysis of corneal endothelial changes in a patient on long-term chlorpromazine therapy [J].
Phua, YS ;
Patel, DV ;
McGhee, CNJ .
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 2005, 243 (07) :721-723
[10]   A cohort study of the ocular safety of anti-ulcer drugs [J].
Rodriguez, LAG ;
Mannino, S ;
Wallander, MA ;
Lindblom, B .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1996, 42 (02) :213-216