Pancytopenia After Allogeneic Bone Marrow Transplant Due to Copper Deficiency

被引:3
作者
Hudspeth, Michelle [1 ]
Turner, Amy [2 ]
Miller, Nicole [3 ]
Lazarchick, John [3 ]
机构
[1] Med Univ S Carolina, Dept Pediat, Div Pediat Hematol Oncol, Charleston, SC 29425 USA
[2] Med Univ S Carolina, Coll Med, Charleston, SC 29425 USA
[3] Med Univ S Carolina, Dept Pathol, Charleston, SC 29425 USA
关键词
myelodysplasia; pancytopenia; copper deficiency; zinc toxicity; MYELODYSPLASIA; ANEMIA; MICE;
D O I
10.1097/MPH.0b013e318290c644
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Pancytopenia occurring 1 year or later after allogeneic bone marrow transplantation typically prompts a primary consideration for relapse. We present the case of a 15-year old-girl who underwent transplantation for therapy-related myelodysplasia secondary to Ewing sarcoma treatment who developed pancytopenia with myelodysplasia 1 year after transplant due to copper deficiency. Copper deficiency is an important consideration in the evaluation of pancytopenia and myelodysplasia in pediatric patients.
引用
收藏
页码:316 / 318
页数:3
相关论文
共 14 条
[1]   Pancytopenia with myelodysplasia due to copper deficiency [J].
Angotti, Lauren B. ;
Post, Ginell R. ;
Robinson, Nancy S. ;
Lewis, Jocelyn A. ;
Hudspeth, Michelle P. ;
Lazarchick, John .
PEDIATRIC BLOOD & CANCER, 2008, 51 (05) :693-695
[2]   Hephaestin is a ferroxidase that maintains partial activity in sex-linked anemia mice [J].
Chen, HJ ;
Attieh, ZK ;
Su, T ;
Syed, BA ;
Gao, H ;
Alaeddine, RM ;
Fox, TC ;
Usta, J ;
Naylor, CE ;
Evans, RW ;
McKie, AT ;
Anderson, GJ ;
Vulpe, CD .
BLOOD, 2004, 103 (10) :3933-3939
[3]   Three Distinct Cases of Copper Deficiency in Hospitalized Pediatric Patients [J].
Dembinski, Karolina ;
Gargasz, Anne Elizabeth ;
Dabrow, Sharon ;
Rodriguez, Lisa .
CLINICAL PEDIATRICS, 2012, 51 (08) :759-762
[4]   Copper deficiency masquerading as myelodysplastic syndrome [J].
Gregg, XT ;
Reddy, V ;
Prchal, JT .
BLOOD, 2002, 100 (04) :1493-1495
[5]   Copper deficiency causes reversible myelodysplasia [J].
Huff, Jason D. ;
Keung, Yi-Kong ;
Thakuri, Mohan ;
Beaty, Micheal W. ;
Hurd, David D. ;
Owen, John ;
Molnar, Istvan .
AMERICAN JOURNAL OF HEMATOLOGY, 2007, 82 (07) :625-630
[6]   Arrested maturation of granulocytes in copper deficient mice [J].
Karimbakas, J ;
Langkamp-Henken, B ;
Percival, SS .
JOURNAL OF NUTRITION, 1998, 128 (11) :1855-1860
[7]   Update on anemia and neutropenia in copper deficiency [J].
Lazarchick, John .
CURRENT OPINION IN HEMATOLOGY, 2012, 19 (01) :58-60
[8]   Clinical features of hematological disorders caused by copper deficiency during long-term enteral nutrition [J].
Nagano, T ;
Toyoda, T ;
Tanabe, H ;
Nagato, T ;
Tsuchida, T ;
Kitamura, A ;
Kasai, G .
INTERNAL MEDICINE, 2005, 44 (06) :554-559
[9]   Copper as an essential nutrient [J].
Olivares, M ;
Uauy, R .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1996, 63 (05) :791-796
[10]   Diagnosis and clinical associations of zinc depletion following bone marrow transplantation [J].
Papadopoulou, A ;
Nathavitharana, K ;
Williams, MD ;
Darbyshire, PJ ;
Booth, IW .
ARCHIVES OF DISEASE IN CHILDHOOD, 1996, 74 (04) :328-331