Efficient kinetic resolution of (±)-4-methyl-Hajos-Parrish ketone by baker's yeast reduction

被引：23

作者：

Hioki, H ^{[1
]}

Hashimoto, T ^{[1
]}

Kodama, M ^{[1
]}

机构：

[1] Tokushima Bunri Univ, Fac Pharmaceut Sci, Yamashiro, Tokushima 7708514, Japan

来源：

TETRAHEDRON-ASYMMETRY | 2000年 / 11卷 / 03期

关键词：

D O I：

10.1016/S0957-4166(00)00010-0

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Kinetic resolution of (+/-)-4-methyl-Hajos-Parrish ketone (+/-)-2a using baker's yeast reduction was investigated. The reaction rate and enantiomeric purity depended on the concentration of substrate and yeast. Under concentrated conditions, (-)-2a and the alcohol (+)-3 were obtained in high enantiomeric excess. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：829 / 834

页数：6

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