Calcitonin gene-related peptide (CGRP) antagonists: blockers of neuronal transmission in migraine

被引：23
|
作者：
Brain, SD [1 ]
机构：
[1] Kings Coll London, Ctr Cardiovasc Biol & Med, London SE1 1UL, England
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 2004年 / 142卷 / 07期
关键词：
CGRP; BIBN4096BS; migraine;
D O I：
10.1038/sj.bjp.0705806
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The neuropeptide calcitonin gene-related peptide (CGRP) is a potent vasodilator that is contained in and released from sensory nerves. CGRP has been implicated in migraine, and the nonpeptide CGRP antagonist BIBN4096BS has been shown to be effective in clinical trials in migraine. To date, it has been largely assumed that the CGRP antagonist is effective due to its ability to block vasodilator activity. Goadsby and co-workers present data that now suggest that CGRP antagonists may also block neuronal transmission in migraine.
引用
收藏
页码：1053 / 1054
页数：2
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