The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease

被引：308
作者：
Giaccia, AJ [1 ]
Simon, MC
Johnson, R
机构：
[1] Stanford Univ, Sch Med, Dept Radiat Oncol, Stanford, CA 94305 USA
[2] Univ Penn, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA
[3] Univ Penn, Howard Hughes Med Inst, Philadelphia, PA 19104 USA
[4] Univ Calif San Diego, Div Biol Sci, La Jolla, CA 92093 USA
来源：
GENES & DEVELOPMENT | 2004年 / 18卷 / 18期
关键词：
hypoxia; HIF; hydroxylases; ion channels;
D O I：
10.1101/gad.1243304
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The ability to sense and respond to changes in oxygen is essential for the survival of prokaryotic and eukaryotic organisms. Oxygen-sensing mechanisms have been developed to maintain cell and tissue homeostasis, as well as to adapt to the chronic low-oxygen conditions found in diseases such as cancer. This report on the first Keystone Meeting on the Biology of Hypoxia will summarize our current understanding of key genes and pathways involved in oxygen sensing that are required for normal development and that are dysregulated in disease states. It will also comment on future directions for this exciting field.
引用
收藏
页码：2183 / 2194
页数：12
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