Intravascular large B-cell lymphoma with a fulminant clinical course: a case report with definite diagnosis post mortem

被引:20
作者
Fiegl, M
Greil, R
Pechlaner, C
Krugmann, J
Dirnhofer, S
机构
[1] Univ Innsbruck, Dept Internal Med, Div Clin Hematol & Oncol, A-6020 Innsbruck, Austria
[2] Univ Innsbruck, Intens Care Unit, A-6020 Innsbruck, Austria
[3] Univ Innsbruck, Inst Pathol, A-6020 Innsbruck, Austria
关键词
angioendotheliomatosis; angiotropic lymphoma; intravascular lymphoma; splenomegaly;
D O I
10.1093/annonc/mdf214
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
A patient is described who presented with pancytopenia, splenomegaly and excessively elevated lactate dehydrogenase levels in concurrence with signs of extramedullary hematopoiesis. Although initially considered in the differential diagnostic spectrum, a highly aggressive lymphoma could not be identified before the patient died, 6 weeks after admission Even an intensive diagnostic work-up including splenectomy and repeated bone marrow biopsies was inconclusive. Finally, the diagnosis of an intravascular large B-cell lymphoma, a highly aggressive clinical subtype of a diffuse large B-cell lymphoma, spreading within vascular structures of multiple organs was established by autopsy. Intravascular large B-cell lymphoma is often not diagnosed before death due to the exclusive intravascular growth pattern of the tumor cells and a fulminant clinical course The heterogeneous clinical features of this lymphoma subtype are discussed.
引用
收藏
页码:1503 / 1506
页数:4
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