Oxidative Modification of Fibrinogen Inhibits Its Transformation into Fibrin under the Effect of Thrombin

被引：18

作者：

Azizova, O. A. ^{[1
]}

Piryazev, A. P. ^{[1
]}

Aseychev, A. V. ^{[1
]}

Shvachko, A. G. ^{[1
]}

机构：

[1] Fed Agcy Publ Hlth & Social Dev, Inst Physicochem Med, Lab Biophys Bases Pathol, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2009年 / 147卷 / 02期

关键词：

fibrinogen; thrombin; oxidative stress;

D O I：

10.1007/s10517-009-0474-6

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Changes in the capacity of fibrinogen subjected to oxidative modification to transform into fibrin under the effect of thrombin and to form a fibrin clot were studied. The effects of oxidized fibrinogen preparations on the clot formation by citrate-treated donor plasma were evaluated by the thrombin time test. Oxidation impaired the capacity of isolated fibrinogen to form a fibrin clot under the effect of thrombin. Addition of oxidized fibrinogen solutions to donor plasma led to prolongation of the plasma clotting time. Maximum addition (33% volume) of oxidized fibrinogen led to a 10-26% prolongation of clotting time in comparison with addition of the same volume of the same solution without fibrinogen.

引用

页码：201 / 203

页数：3

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