Insulin-like growth factor-II induces hypertrophy of adult cardiomyocytes via two alternative pathways

被引：26
|
作者：
Huang, CY [1 ]
Hao, LY [1 ]
Buetow, DE [1 ]
机构：
[1] Univ Illinois, Dept Mol & Integrat Physiol, Urbana, IL 61801 USA
来源：
CELL BIOLOGY INTERNATIONAL | 2002年 / 26卷 / 08期
关键词：
cardiomyocyte hypertrophy; insulin-like growth factor (IGF)-II; IGF-I receptor; lysosomes;
D O I：
10.1006/cbir.2002.0919
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Insulin-like growth factor (IGF)-II is known to induce hypertrophy of isolated adult rat ventricular cardiomyocytes cultured in the absence of serum. However, it is not known how the growth factor exerts this hypertrophic effect. We show here that IGF-II induces hypertrophy of the cultured cardiomyocytes via two alternative pathways: (1) an IGF-I receptor-dependent pathway, or (2) a lysosome-dependent pathway when the IGF-I receptor-dependent pathway is blocked. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：737 / 739
页数：3
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