Schwann cell precursors contribute to skeletal formation during embryonic development in mice and zebrafish

被引：52

作者：

Xie, Meng ^{[1
]}

Kamenev, Dmitrii ^{[2
]}

Kaucka, Marketa ^{[1
,3
]}

Kastriti, Maria Eleni ^{[1
,3
]}

Zhou, Baoyi ^{[1
]}

Artemov, Artem V. ^{[3
,4
]}

Storer, Mekayla ^{[5
]}

Fried, Kaj ^{[2
]}

Adameyko, Igor ^{[1
,3
]}

Dyachuk, Vyacheslav ^{[2
,6
]}

Chagin, Andrei S. ^{[1
,4
]}

机构：

[1] Karolinska Inst, Dept Physiol & Pharmacol, S-17165 Solna, Sweden

[2] Karolinska Inst, Dept Neurosci, C4, S-17165 Solna, Sweden

[3] Med Univ Vienna, Dept Mol Neurosci, A-1090 Vienna, Austria

[4] Sechenov Univ, Inst Regenerat Med, Moscow 119992, Russia

[5] Hosp Sick Children, Program Neurosci & Mental Hlth, Toronto, ON M5G 1L7, Canada

[6] Russian Acad Sci, Far Eastern Branch, Natl Sci Ctr Marine Biol, Vladivostok 690041, Russia

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2019年 / 116卷 / 30期

基金：

瑞典研究理事会; 俄罗斯基础研究基金会; 俄罗斯科学基金会; 加拿大健康研究院;

关键词：

Schwann cell precursors; mesenchymal cells; cartilage; bone; glia; MESENCHYMAL STEM-CELLS; NEURAL CREST; EVOLUTIONARY ORIGIN; GLIAL-CELLS; DIFFERENTIATION; SPECIFICATION; TRANSCRIPTION; EXPRESSION; NEURONS; MODEL;

D O I：

10.1073/pnas.1900038116

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Immature multipotent embryonic peripheral glial cells, the Schwann cell precursors (SCPs), differentiate into melanocytes, parasympathetic neurons, chromaffin cells, and dental mesenchymal populations. Here, genetic lineage tracing revealed that, during murine embryonic development, some SCPs detach from nerve fibers to become mesenchymal cells, which differentiate further into chondrocytes and mature osteocytes. This occurred only during embryonic development, producing numerous craniofacial and trunk skeletal elements, without contributing to development of the appendicular skeleton. Formation of chondrocytes from SCPs also occurred in zebrafish, indicating evolutionary conservation. Our findings reveal multipotency of SCPs, providing a developmental link between the nervous system and skeleton.

引用

页码：15068 / 15073

页数：6

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