Antileishmaniasis Activity of Flavonoids from Consolida oliveriana

被引：50

作者：

Marin, Clotilde ^{[1
]}

Boutaleb-Charki, Samira ^{[1
]}

Diaz, Jesus G. ^{[2
]}

Huertas, Oscar ^{[1
]}

Rosales, Maria J. ^{[1
]}

Perez-Cordon, Gregorio ^{[1
]}

Guitierrez-Sanchez, Ramon ^{[3
]}

Sanchez-Moreno, Manuel ^{[1
]}

机构：

[1] Univ Granada, Dept Parasitol, E-18071 Granada, Spain

[2] Univ La Laguna, Dept Chem, Inst Univ BioOrgan Antonio Gonzalez, E-38206 Tenerife, Spain

[3] Univ Granada, Dept Stat, E-18071 Granada, Spain

来源：

JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 06期

关键词：

NATURAL-PRODUCTS; LEISHMANIA-DONOVANI; ENERGY-METABOLISM; PLANT-EXTRACTS; ALKALOIDS; MACA; CONSTITUENTS; CHEMOTHERAPY; DERIVATIVES;

D O I：

10.1021/np8008122

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A set of flavonoids from Consolida oliveriana, kaempferol (1), quercetin (2), trifolin (3), and acetyl hyperoside (5) and their O-acetyl derivatives (1a, 2a, 3a), and octa-O-acetylhyperoside (4) showed leishmanicidal activity against promastigote as well as amastigote forms of Leishmania spp. The cellular proliferation, metabolic, and ultrastructural studies showed that the acetylated compounds 2a, 3a, and 4 were highly active against Leishmania (V.) peruviana, while 2a as well as 4 were effective against Leishmania (V.) braziliensis. These compounds were not cytotoxic and are effective at similar concentrations up to or lower than the reference drugs (pentostam and glucantim).

引用

页码：1069 / 1074

页数：6

共 44 条

[1] Cutaneous leishmaniasis [J].