Synthesis and antimicrobial activity of new piperazine-based heterocyclic compounds

被引：21

作者：

Ozdemir, Serap Basoglu ^{[1
]}

Cebeci, Yildiz Uygun ^{[1
]}

Bayrak, Hacer ^{[2
]}

Mermer, Arif ^{[1
]}

Ceylan, Sule ^{[3
]}

Demirbas, Ahmet ^{[1
]}

Karaoglu, Sengul Alpay ^{[4
]}

Demirbas, Neslihan ^{[1
]}

机构：

[1] Karadeniz Tech Univ, Dept Chem, TR-61080 Trabzon, Turkey

[2] Karadeniz Tech Univ, Dept Chem & Chem Proc Technol, TR-61080 Trabzon, Turkey

[3] Artvin Coruh Univ, Dept Occupat Hlth & Safety, Artvin, Turkey

[4] Recep Tayyip Erdogan Univ, Dept Biol, Rize, Turkey

来源：

HETEROCYCLIC COMMUNICATIONS | 2017年 / 23卷 / 01期

关键词：

antimicrobial activity; conazole; Mannich base; microwave; piperazine; MICROWAVE-ASSISTED SYNTHESIS; HYBRID MOLECULES; ONE-POT; BIOLOGICAL EVALUATION; DERIVATIVES; BEARING; DESIGN;

D O I：

10.1515/hc-2016-0125

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The hydrazide 5, that was obtained from -1-(4-fluorophenyl) piperazine (1), was converted to the cor-responding carbothioamides 6a-c by the reaction with alkyl(aryl) isothiocyanates. The synthesis of conazole analogs 10a-f was performed via the intermediary of triazoles 7a-c. The condensation of triazoles 7a-c with -several -heterocyclic amines in the presence of formalde-hyde afforded the corresponding N-aminoalkylated tria-zoles 11-14. The effect of different catalysts and solvents on conventional and microwave (MW)-prompted reac-tions was examined. The synthesized compounds were screened for their antimicrobial activities.

引用

页码：43 / 54

页数：12

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