Synthesis and antimicrobial activity of new piperazine-based heterocyclic compounds

The hydrazide 5, that was obtained from -1-(4-fluorophenyl) piperazine (1), was converted to the cor-responding carbothioamides 6a-c by the reaction with alkyl(aryl) isothiocyanates. The synthesis of conazole analogs 10a-f was performed via the intermediary of triazoles 7a-c. The condensation of triazoles 7a-c with -several -heterocyclic amines in the presence of formalde-hyde afforded the corresponding N-aminoalkylated tria-zoles 11-14. The effect of different catalysts and solvents on conventional and microwave (MW)-prompted reac-tions was examined. The synthesized compounds were screened for their antimicrobial activities.