Early bioavailability of paracetamol after oral or intravenous administration

Background: Paracetamol is a peripherally acting analgesic commonly,used in multimodal post-operative pain management, to reduce the need for, more potent analgesic's with their unwanted side-effects. The dose And optimal galenical form for achieving analgesic concentrations is not well defined. The Primary aim of this pilot project was to study the early bioavailability for two fixed doses of. orally administrated paracetamol and one dose of intravenous propacetamoll all of which,were given after minor surgery. Methods: Thirty-five patients undergoing day. surgery were divided into five groups, seven patients each. Groups received either 1 g of an ordinary paracetamol tablet, 2g of an ordinary paracetamol. tablet, 1g of a bicarbonate paracetamol tablet, 2g of a bicarbonate paracetamol tablet or 2g intravenously of prodrug propacetamol. We studied the plasma concentration of paracetamol during the first 80 min after administration. Results: Within 40 min, intravenous propacetamol gave a median plasma paracetamol concentration of 85 mumol/l (range 65-161) and decreased thereafter. After oral administration, median plasma paracetamol concentration increased with increasing dose and time, but there were huge inter-individual differences at all time points studied. At 80 min after. oral paracetamol the median plasma concentrations were 36 and 1291 mumol/l for the 1- and 2-g groups, respectively, with an overall range between 0 and 300 mumol/l. Conclusion: Oral administration of paracetamol as part of multimodal pain management immediately post-operatively resulted in a huge and unpredictable variation in plasma concentration compared with the intravenous administration.