Diterpenoid alkaloids from Aconitum brevicalcaratum as autophagy inducers

被引：12

作者：

Jiang, Haiyue ^{[1
]}

Huang, Shuai ^{[1
,2
]}

Gao, Feng ^{[1
]}

Zhen, Yongqi ^{[1
]}

Li, Chunying ^{[2
]}

Zhou, Xianli ^{[1
]}

机构：

[1] Southwest Jiaotong Univ, Sch Life Sci & Engn, Chengdu, Sichuan, Peoples R China

[2] Georgia State Univ, Inst Biomed Sci, Ctr Mol & Translat Med, Atlanta, GA 30303 USA

来源：

NATURAL PRODUCT RESEARCH | 2019年 / 33卷 / 12期

基金：

中国国家自然科学基金; 美国国家卫生研究院;

关键词：

Aconitum brevicalcaratum (Finet et Gagnep; ) Diels; brevicanine; autophagy; HCT116; ROOTS;

D O I：

10.1080/14786419.2018.1437435

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new C-19 diterpenoid alkaloid, brevicanine (1) and six known ones (2-7) were isolated from Aconitum brevicalcaratum (Finet et Gagnep.) Diels. Their structures were elucidated on the basis of extensive spectroscopic analyses. The cytotoxicity of those compounds was investigated against HCT116 human cancer cell line, which showed none of them possessing considerable anti-proliferative activities. To evaluate the autophagy effect of compounds 1-7, Western blot was used to detect the expression of autophagic marker by stimulating human cancer HCT116 cells. The results showed that compound 6 induced protective autophagy in HCT116 cells. Mechanistic insight showed that compound 6 induced protective autophagy through p53 activation, ERK1/2 and p38 MAPK signaling cascade. [GRAPHICS] .

引用

页码：1741 / 1746

页数：6

共 19 条

[1] A new C20-diterpenoid alkaloid from Aconitum soongaricum var. pubescens [J].

Chen, Lin ;

Shan, Lianhai ;

Xu, Wenliang ;

Zhang, Jifa ;

Huang, Shuai ;

Zhou, Xianli .

NATURAL PRODUCT RESEARCH, 2017, 31 (05) :523-528

[2] Therapeutic Targeting of Autophagy in Disease: Biology and Pharmacology [J].

Cheng, Yan ;

Ren, Xingcong ;

Hait, William N. ;

Yang, Jin-Ming .

PHARMACOLOGICAL REVIEWS, 2013, 65 (04) :1162-1197

[3] Norditerpenoids and Dinorditerpenoids from the Seeds of Podocarpus nagi as Cytotoxic Agents and Autophagy Inducers [J].

Feng, Zhe-Ling ;

Zhang, Le-Le ;

Zheng, Yuan-Dong ;

Liu, Qian-Yu ;

Liu, Jing-Xin ;

Feng, Lu ;

Huang, Li ;

Zhang, Qing-Wen ;

Lu, Jin-Jian ;

Lin, Li-Gen .

JOURNAL OF NATURAL PRODUCTS, 2017, 80 (07) :2110-2117

[4] New alkaloids from Aconitum taipaicum and their cytotoxic activities [J].

Guo, Zeng-Jun ;

Xu, Ying ;

Zhang, Hui ;

Li, Meng-Yi ;

Xi, Ke .

NATURAL PRODUCT RESEARCH, 2014, 28 (03) :164-168

[5]

Hao XJ, 1985, ACTA BOT YUNNANICA, V7, P217

[6] Pyrrolizidine alkaloids from Liparis nervosa with inhibitory activities against LPS-induced NO production in RAW264.7 macrophages [J].

Huang, Shuai ;

Zhou, Xian-li ;

Wang, Cui-juan ;

Wang, You-song ;

Xiao, Feng ;

Shan, Lian-hai ;

Guo, Zhi-yun ;

Weng, Jie .

PHYTOCHEMISTRY, 2013, 93 :154-161

[7]

[IBCAS] Institute of Botany Chinese Academy of Sciences and Institute of Materia Medica Chinese Academy of Medical Sciences, 1979, FLOR REIP POP SIN, V27, P160

[8]

Jia MR, 2005, ZHONGGUO MINZUZHI YA, P8

[9] Docosahexaenoic acid induces autophagy through p53/AMPK/mTOR signaling in human cancer cells [J].

Jing, Kiapeng ;

Song, Kyoung-Sub ;

Jeong, Soyeon ;

Kim, Nayeong Kim ;

Jeong, Soyeon ;

Heo, Jun-Young ;

Park, Ji-Hoon ;

Seo, Kang-Sik ;

Kwon, Hyun-Joo ;

Park, Hae-Duck ;

Han, Chang ;

Wu, Tong ;

Park, Jong-Il ;

Park, Seung-Kiel ;

Kweon, Gi-Ryang ;

Yoon, Wan-Hee ;

Hwang, Byung-Doo ;

Lim, Kyu .

CANCER RESEARCH, 2011, 71

[10] Autophagy of Mitochondria: A Promising Therapeutic Target for Neurodegenerative Disease [J].

Kamat, Pradip K. ;

Kalani, Anuradha ;

Kyles, Philip ;

Tyagi, Suresh C. ;

Tyagi, Neetu .

CELL BIOCHEMISTRY AND BIOPHYSICS, 2014, 70 (02) :707-719

← 1 2 →