Ruthenium-Catalyzed Site-selective Enone Carbonyl Directed ortho-C-H Activation of Aromatics and Heteroaromatics with Alkenes

An efficient and versatile protocol for enone carbonyl directed ortho C-H activation of aromatics and heteroaromatics with alkenes for the construction of functionalized ortho-olefinated chalcone derivatives in excellent yields in a regio- and stereoselective fashion has been developed for the first time. This general protocol involves chelation assisted oxidative coupling in the presence of ruthenium catalyst through C-H bond activation. This protocol has been further emphasized by the exhibition of functional group tolerance.