Dual selective iron chelating probes with a potential to monitor mitochondrial labile iron pools

被引：26

作者：

Abbate, Vincenzo ^{[1
]}

Reelfs, Olivier ^{[2
]}

Kong, Xiaole ^{[1
]}

Pourzand, Charareh ^{[2
]}

Hider, Robert C. ^{[1
]}

机构：

[1] Kings Coll London, Inst Pharmaceut Sci, London SE1 9NH, England

[2] Univ Bath, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England

来源：

CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 04期

基金：

英国生物技术与生命科学研究理事会;

关键词：

PEPTIDE ANTIOXIDANTS; OXIDATIVE STRESS; ULTRAVIOLET; RADIATION; DISEASE; DESIGN;

D O I：

10.1039/c5cc06170a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Mitochondria-targeted peptides incorporating dual fluorescent and selective iron chelators have been designed as novel biosensors for the mitochondrial labile iron pool. The probes were demonstrated to specifically co-localize with mitochondria and their fluorescence emission was found to be sensitive to the presence of iron.

引用

页码：784 / 787

页数：4

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