Cell surface receptors, virus entry and tropism of primate lentiviruses

被引：175

作者：

Clapham, PR

McKnight, A

机构：

[1] Univ Massachusetts, Sch Med, Dept Mol Genet & Microbiol, Program Mol Med,Ctr AIDS Res, Worcester, MA 01605 USA

[2] UCL, Windeyer Inst Med Sci, Dept Immunol & Mol Pathol, Wohl Vir Ctr, London W1P 6DB, England

来源：

JOURNAL OF GENERAL VIROLOGY | 2002年 / 83卷

关键词：

D O I：

10.1099/0022-1317-83-8-1809

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Human immunodeficiency virus (HIV) exploits cell surface receptors to attach to and gain entry into cells. The HIV envelope spike glycoprotein on the surface of virus particles binds both CD4 and a seven-transmembrane coreceptor. These interactions trigger conformational changes in the envelope spike that induce fusion of viral and cellular membranes and entry of the viral core into the cell cytoplasm. Other cell surface receptors also interact with gp120 and aid attachment of virus particles. This review describes these receptors, their roles in HIV entry and their influence on cell tropism.

引用

页码：1809 / 1829

页数：21

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