Oxidative and endoplasmic reticulum stress in respiratory disease

被引：61

作者：

Chen, Alice C-H ^{[1
,2
]}

Burr, Lucy ^{[3
,4
]}

McGuckin, Michael A. ^{[5
]}

机构：

[1] Univ Queensland, Diamantina Inst, Fac Med, Brisbane, Qld, Australia

[2] Royal Prince Alfred Hosp, Dept Cell & Mol Therapy, Sydney, NSW, Australia

[3] Univ Queensland, Dept Resp Med, Mater Adult Hosp, Raymond Tce, South Brisbane, Qld, Australia

[4] Univ Queensland, Mater Res Inst, Raymond Tce, South Brisbane, Qld, Australia

[5] Univ Queensland, Inflammatory Dis Biol & Therapeut Grp, Translat Res Inst, Mater Res Inst, Brisbane, Qld, Australia

来源：

CLINICAL & TRANSLATIONAL IMMUNOLOGY | 2018年 / 7卷 / 06期

基金：

英国医学研究理事会;

关键词：

cystic fibrosis; endoplasmic reticulum stress; inflammation; lung disease; oxidative stress; protein misfolding; respiratory epithelium; IDIOPATHIC PULMONARY-FIBROSIS; UNFOLDED PROTEIN RESPONSE; MUC5B PROMOTER POLYMORPHISM; AIRWAY MICROBIOTA COMPOSITION; OBSTRUCTIVE LUNG-DISEASES; SYNCYTIAL VIRUS-INFECTION; NON-CF BRONCHIECTASIS; CYSTIC-FIBROSIS; EPITHELIAL-CELLS; ER STRESS;

D O I：

10.1002/cti2.1019

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Oxidative stress and endoplasmic reticulum (ER) stress are related states that can occur in cells as part of normal physiology but occur frequently in diseases involving inflammation. In this article, we review recent findings relating to the role of oxidative and ER stress in the pathophysiology of acute and chronic nonmalignant diseases of the lung, including infections, cystic fibrosis, idiopathic pulmonary fibrosis and asthma. We also explore the potential of drugs targeting oxidative and ER stress pathways to alleviate disease.

引用

页数：13

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