Synthetic Entries to and Biological Activity of Pyrrolopyrimidines

被引：150

作者：

De Coen, Laurens M. ^{[1
]}

Heugebaert, Thomas S. A. ^{[1
]}

Garcia, Daniel ^{[1
]}

Stevens, Christian V. ^{[1
]}

机构：

[1] Univ Ghent, Dept Sustainable Organ Chem & Technol, B-9000 Ghent, Belgium

来源：

CHEMICAL REVIEWS | 2016年 / 116卷 / 01期

关键词：

PURINE NUCLEOSIDE PHOSPHORYLASE; ADENOSINE-KINASE-INHIBITORS; TRANSITION-STATE ANALOGS; SELECTIVE ALPHA(1)-ADRENOCEPTOR LIGANDS; COUPLED FOLATE TRANSPORTER; STRUCTURE-BASED DESIGN; VIRUS-RNA REPLICATION; DIELS-ALDER REACTION; ONE-POT SYNTHESIS; GYRASE B GYRB;

D O I：

10.1021/acs.chemrev.5b00483

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This review summarizes recent literature (2000-2015) on the synthesis and pharmaceutical properties of pyrrolopyrimidines. These modified pyrimidine bases, fused to a pyrrole ring, and their corresponding nucleosides display a broad applicability in medicinal chemistry. This overview is divided into three main sections, according to the respective isomers: pyrrolo[2,3-d]pyrimidines, pyrrolo[3,2-d]pyrimidines, and pyrrolo[3,4-d]pyrimidines. Each section contains a description of common retro-synthetic strategies, with particular attention for newly reported synthetic entries to the scaffold. Next, the synthetic strategies and the ways in which the scaffolds can be further modified are exemplified according to the biological properties of the obtained products.

引用

页码：80 / 139

页数：60

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