Decline in the rate of genotypic resistance to antiretroviral drugs in recent HIV seroconverters in Madrid

被引：25

作者：

de Mendoza, C ^{[1
]}

del Romero, J

Rodríguez, C

Corral, A

Soriano, V

机构：

[1] Hosp Carlos III, Inst Salud Carlos III, Infect Dis Serv, Madrid, Spain

[2] Serv Reg Salud, Ctr Sanitario Sandoval, Madrid, Spain

来源：

AIDS | 2002年 / 16卷 / 13期

关键词：

D O I：

10.1097/00002030-200209060-00019

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Genotypic resistance to antiretroviral drugs was analysed in plasma from 57 acute or recent HIV seroconverters in Madrid. The overall prevalence of drug-associated primary resistance mutations was 25.8% in 1997-1999, but declined to 3.8% in 2000-2001. The lower rate in recent years suggested that most new HIV infections derive from viraemic individuals unaware of their HIV-positive status, rather than from those failing antiretroviral treatment. Drug-resistance testing is thus not required before beginning antiretroviral therapy.

引用

页码：1830 / 1832

页数：3

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