Injectable Poly(amidoamine)-poly(ethylene glycol)-poly(amidoamine) Triblock Copolymer Hydrogel with Dual Sensitivities: pH and Temperature

被引：59

作者：

Nguyen, Minh Khanh ^{[1
]}

Park, Dong Kuk ^{[1
]}

Lee, Doo Sung ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Dept Polymer Sci & Engn, Suwon 440746, Gyeonggi Do, South Korea

来源：

BIOMACROMOLECULES | 2009年 / 10卷 / 04期

关键词：

THERMOSENSITIVE HYDROGEL; POLYMERS; FTIR; PROTONATION; PROTEIN; STATE;

D O I：

10.1021/bm900183j

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel triblock copolymer for use in an injectable pH- and temperature-sensitive hydrogel is synthesized by conjugating poly(amidoamine) (PAA) to poly(ethylene glycol): poly(amidoamine)-poly(ethylene glycol)poly(amidoamine) (PAA-PEG-PAA). The polymer was characterized with H-1 NMR and gel permeation chromatography in the diluents CDC13 and CHC13, respectively. The PAA block acts as a pH- and temperature-sensitive block. The PAA-PEG-PAA copolymer in aqueous solution (12.5 wt %) underwent a sol-gel transition as a function of pH and temperature. After injection into a rat, the copolymer solution (12.5 wt %) was immediately changed to a gel.

引用

页码：728 / 731

页数：4

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