Integrating the active process of hair cells with cochlear function

被引：235

作者：

Hudspeth, A. J. ^{[1
,2
]}

机构：

[1] Rockefeller Univ, Howard Hughes Med Inst, New York, NY 10065 USA

[2] Rockefeller Univ, Lab Sensory Neurosci, New York, NY 10065 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2014年 / 15卷 / 09期

关键词：

SPONTANEOUS OTOACOUSTIC EMISSIONS; MECHANOELECTRICAL-TRANSDUCTION; TIP-LINK; BASILAR-MEMBRANE; INNER-EAR; MECHANOSENSITIVE CHANNELS; ELECTRICAL-STIMULATION; SOMATIC MOTILITY; BUNDLE MOVEMENTS; FAST ADAPTATION;

D O I：

10.1038/nrn3786

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Uniquely among human senses, hearing is not simply a passive response to stimulation. Our auditory system is instead enhanced by an active process in cochlear hair cells that amplifies acoustic signals several hundred-fold, sharpens frequency selectivity and broadens the ear's dynamic range. Active motility of the mechanoreceptive hair bundles underlies the active process in amphibians and some reptiles; in mammals, this mechanism operates in conjunction with prestin-based somatic motility. Both individual hair bundles and the cochlea as a whole operate near a dynamical instability, the Hopf bifurcation, which accounts for the cardinal features of the active process.

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收藏

页码：600 / 614

页数：15

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