Abnormal white matter connections between medial frontal regions predict symptoms in patients with first episode schizophrenia

被引：19

作者：

Ohtani, Toshiyuki ^{[1
,2
,8
]}

Bouix, Sylvain ^{[1
]}

Lyall, Amanda E. ^{[1
]}

Hosokawa, Taiga ^{[1
,2
,9
]}

Saito, Yukiko ^{[1
,10
]}

Melonakos, Eric ^{[1
]}

Westin, Carl-Fredrik ^{[7
]}

Seidman, Larry J. ^{[3
,4
]}

Goldstein, Jill ^{[4
]}

Mesholam-Gately, Raquelle ^{[3
]}

Petryshen, Tracey ^{[5
,6
]}

Wojcik, Joanne ^{[4
]}

Kubicki, Marek ^{[1
,2
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Psychiat Neuroimaging Lab,Dept Psychiat, Boston, MA 02115 USA

[2] VA Boston Healthcare Syst, Boston, MA USA

[3] Harvard Univ, Beth Israel Deaconess Med Ctr, Massachusetts Mental Hlth Ctr, Publ Psychiat Div,Dept Psychiat,Sch Med, Boston, MA 02215 USA

[4] Harvard Univ, Sch Med, Dept Psychiat, Massachusetts Gen Hosp, Boston, MA 02115 USA

[5] Broad Inst MIT & Harvard, Stanley Ctr Psychiat Res, Boston, MA USA

[6] Massachusetts Gen Hosp, Ctr Human Genet Res, Psychiat & Neurodev Genet Unit, Boston, MA 02114 USA

[7] Harvard Univ, Brigham & Womens Hosp, Sch Med, Surg Planning Lab,MRI Div,Dept Radiol, Boston, MA 02115 USA

[8] Chiba Univ, Safety & Hlth Org, Chiba, Chiba, Japan

[9] Tsuchida Hosp, Tokyo, Japan

[10] Kansai Med Univ, Dept Neuropsychiat, Moriguchi, Osaka 570, Japan

来源：

CORTEX | 2015年 / 71卷

基金：

美国国家卫生研究院;

关键词：

White matter; Fractional anisotropy; Orbitofrontal cortex; Anterior cingulate cortex; First episode schizophrenia; ANTERIOR CINGULATE CORTEX; DIFFUSION TENSOR; ORBITOFRONTAL CORTEX; CORPUS-CALLOSUM; 1ST-EPISODE SCHIZOPHRENIA; FUNCTIONAL NEUROANATOMY; ONSET SCHIZOPHRENIA; INTEGRITY; EMOTION; TRACTOGRAPHY;

D O I：

10.1016/j.cortex.2015.05.028

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Introduction: The medial orbitofrontal cortex (mOFC) and rostral part of anterior cingulate cortex (rACC) have been suggested to be involved in the neural network of salience and emotional processing, and associated with specific clinical symptoms in schizophrenia. Considering the schizophrenia dysconnectivity hypothesis, the connectivity abnormalities between mOFC and rACC might be associated with clinical characteristics in first episode schizophrenia patients (FESZ). Methods: After parcellating mOFC into the anterior and posterior part, diffusion properties of the mOFC-rACC white matter connections for 21 patients with FESZ and 21 healthy controls (HCs) were examined using stochastic tractography, one of the most effective Diffusion Tensor Imaging (DTI) methods for examining tracts between adjacent gray matter (GM) regions. Results: Fractional anisotropy (FA) reductions were observed in bilateral posterior, but not anterior mOFC-rACC connections (left: p < .0001; right: p < .0001) in FESZ compared to HCs. In addition, reduced FA in the left posterior mOFC-rACC connection was associated with more severe anhedonia-asociality (rho = -.633, p = .006) and total score (rho = -.520, p = .032) in the Scale for the Assessment of Negative Symptoms (SANS); reduced FA in the right posterior mOFC-rACC connection was associated with more severe affective flattening (rho = -.644, p = .005), total score (rho = -.535, p = .027) in SANS, hallucinations (rho = -.551, p = .018), delusions (rho = -.632, p = .005) and total score (rho = -.721, p = .001) in the Scale for the Assessment of Positive Symptoms (SAPS) in FESZ. Conclusions: The observed white matter abnormalities within the connections between mOFC and rACC might be associated with the psychopathology of the early stage of schizophrenia. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：264 / 276

页数：13

共 82 条

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