Study of vitamin E microencapsulation and controlled release from chitosan/sodium lauryl ether sulfate microcapsules

被引:72
作者
Budincic, Jelena Milinkovic [1 ]
Petrovic, Lidija [1 ]
Dekic, Ljiljana [2 ]
Fraj, Jadranka [1 ]
Bucko, Sandra [1 ]
Katona, Jaroslav [1 ]
Spasojevic, Ljiljana [1 ]
机构
[1] Univ Novi Sad, Fac Technol Novi Sad, Dept Biotechnol & Pharmaceut Engn, Novi Sad, Serbia
[2] Univ Belgrade, Fac Pharm, Dept Pharmaceut Technol & Cosmetol, Belgrade, Serbia
关键词
Chitosan; Glutaraldehyde; Formaldehyde; Vitamin E; Microencapsulation; Controlled release; ALPHA-TOCOPHEROL; DODECYL-SULFATE; DRUG-RELEASE; POLYELECTROLYTE COMPLEXES; DELIVERY-SYSTEMS; WALL MATERIALS; MICROSPHERES; ENCAPSULATION; CARRIER; OIL;
D O I
10.1016/j.carbpol.2020.116988
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
Potential benefit of microencapsulation is its ability to deliver and protect incorporated ingredients such as vitamin E. Microcapsule wall properties can be changed by adding of coss-linking agents that are usually considered toxic for application. The microcapsules were prepared by a spray-drying technique using coacervation method, by depositing the coacervate formed in the mixture of chitosan and sodium lauryl ether sulfate to the oil/water interface. All obtained microcapsules suspensions had slightly lower mean diameter compared to the starting emulsion (6.85 +/- 0.213 mu m), which shows their good stability during the drying process. The choice and absence of cross-linking agents had influence on kinetics of vitamin E release. Encapsulation efficiency of microcapsules without cross-linking agent was 73.17 +/- 0.64 %. This study avoided the use of aldehydes as cross-linking agents and found that chitosan/SLES complex can be used as wall material for the microencapsulation of hydrophobic active molecules in cosmetic industry.
引用
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页数:8
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