Radiation-induced bystander signalling in cancer therapy

被引：646

作者：

Prise, Kevin M. ^{[1
]}

O'Sullivan, Joe M. ^{[1
,2
]}

机构：

[1] Queens Univ Belfast, Ctr Canc Res & Cell Biol, Belfast BT9 7BL, Antrim, North Ireland

[2] Belfast City Hosp, No Ireland Canc Ctr, Belfast BT9 7AB, Antrim, North Ireland

来源：

NATURE REVIEWS CANCER | 2009年 / 9卷 / 05期

基金：

美国国家卫生研究院;

关键词：

RAT LUNG IRRADIATION; OUT-OF-FIELD; MEDIATED INTERCELLULAR COMMUNICATION; TARGETED CYTOPLASMIC IRRADIATION; INDUCED GENOMIC INSTABILITY; SISTER-CHROMATID EXCHANGES; DNA-DAMAGE RESPONSE; VERY-LOW FLUENCES; IONIZING-RADIATION; ALPHA-PARTICLES;

D O I：

10.1038/nrc2603

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Our understanding of how radiation kills normal and tumour cells has been based on an intimate knowledge of the direct induction of DNA damage and its cellular consequences. What has become clear is that, as well as responses to direct DNA damage, cell-cell signalling - known as the bystander effect - mediated through gap junctions and inflammatory responses may have an important role in the response of cells and tissues to radiation exposure and also chemotherapy agents. This Review Outlines the key aspects of radiation-induced intercellular signalling and assesses its relevance for existing and future radiation-based therapies.

引用

页码：351 / 360

页数：10

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