3-Hydroxybutanolide derivatives and flavonoid glucosides from Anoectochilus roxburghii

被引：17

作者：

Liu, Qing ^{[1
]}

Ha, Wei ^{[2
,3
]}

Liu, Zhenling ^{[2
,3
]}

Xu, Jing ^{[2
,3
]}

Tian, Yueli ^{[3
]}

Zhou, Xinwen ^{[4
]}

Mu, Xinpeng ^{[3
]}

机构：

[1] Huaqiao Univ, Dept Chem Engn & Pharm, Coll Chem Engn, Xiamen 362011, Fujian, Peoples R China

[2] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

[3] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China

[4] Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2014年 / 8卷

基金：

美国国家科学基金会; 中国国家自然科学基金;

关键词：

Anoectochilus roxburghii; Orchidaceae; 3-Hydroxybutanolide derivatives; Flavonoid glucoside; Antioxidant activities; MOLECULAR DOCKING; KINSENOSIDE; CONSTITUENTS; GLYCOSIDES; MUTANTS;

D O I：

10.1016/j.phytol.2014.02.013

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new 3-hydroxybutanolide derivatives, named kinsenbenol (1), kinsendioside A (2) and kinsendioside B (3) (kinsendiosides A and B were a mixture), and one new flavonoid glucoside, named roxburoside (4), were isolated from Anoectochilus roxburghii. The structures were elucidated using NMR spectroscopy, X-ray crystallography, and chemical derivatization. Compound 1, the acetates of 2 (2a) and 3 (3a), 4, and the known compounds 5-8 were evaluated their antioxidant activities using a modified thiobarbituric acid assay. Molecular docking verified that the substantial antioxidant activities of 2a, 3a, and 4 partially resulted from their effect on the activity of SOD in cells. This study has not only enriched the family of active molecules from the whole plant of A. roxburghii, but also improved the understanding of biological activity from molecular level. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

引用

页码：109 / 115

页数：7

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