The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis

被引：642
作者：
Carmell, MA
Xuan, ZY
Zhang, MQ
Hannon, GJ
机构：
[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
[2] SUNY Stony Brook, Genet Program, Stony Brook, NY 11794 USA
来源：
GENES & DEVELOPMENT | 2002年 / 16卷 / 21期
关键词：
D O I：
10.1101/gad.1026102
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In conclusion, Argonaute proteins comprise a highly conserved protein family that is involved in a variety of RNA silencing phenomena in a diverse set of organisms. Perhaps through RNAi-related pathways or possibly also through distinct mechanisms, Argonaute family members have a variety of biological roles. These include regulation of development and determination of stem-cell character. Through an ever-advancing understanding of the biochemistry and genetics of the Argonaute family, we may ultimately reveal the reach of these pathways into the basic biological mechanisms that underlie a variety of human diseases.
引用
收藏
页码：2733 / 2742
页数：10
相关论文
共 66 条
[31]   RNAi is activated during Drosophila oocyte maturation in a manner dependent on aubergine and spindle-E [J].
Kennerdell, JR ;
Yamaguchi, S ;
Carthew, RW .
GENES & DEVELOPMENT, 2002, 16 (15) :1884-1889
[32]   Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C-elegans [J].
Ketting, RF ;
Fischer, SEJ ;
Bernstein, E ;
Sijen, T ;
Hannon, GJ ;
Plasterk, RHA .
GENES & DEVELOPMENT, 2001, 15 (20) :2654-2659
[33]   Yb modulates the divisions of both germline and somatic stem cells through piwi- and hh-mediated mechanisms in the Drosophila ovary [J].
King, FJ ;
Szakmary, A ;
Cox, DN ;
Lin, HF .
MOLECULAR CELL, 2001, 7 (03) :497-508
[34]   A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans [J].
Knight, SW ;
Bass, BL .
SCIENCE, 2001, 293 (5538) :2269-2271
[35]   Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence, genomic organization, localization to chromosomal bands 1p34-p35, and expression [J].
Koesters, R ;
Adams, V ;
Betts, D ;
Moos, R ;
Schmid, M ;
Siermann, A ;
Hassam, S ;
Weitz, S ;
Lichter, P ;
Heitz, PU ;
Doeberitz, MV ;
Briner, J .
GENOMICS, 1999, 61 (02) :210-218
[36]   Two mouse piwi-related genes:: miwi and mili [J].
Kuramochi-Miyagawa, S ;
Kimura, T ;
Yomogida, K ;
Kuroiwa, A ;
Tadokoro, Y ;
Fujita, Y ;
Sato, M ;
Matsuda, Y ;
Nakano, T .
MECHANISMS OF DEVELOPMENT, 2001, 108 (1-2) :121-133
[37]   Identification of novel genes coding for small expressed RNAs [J].
Lagos-Quintana, M ;
Rauhut, R ;
Lendeckel, W ;
Tuschl, T .
SCIENCE, 2001, 294 (5543) :853-858
[38]   Micro RNAs are complementary to 3′ UTR sequence motifs that mediate negative post-transcriptional regulation [J].
Lai, EC .
NATURE GENETICS, 2002, 30 (04) :363-364
[39]   An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans [J].
Lau, NC ;
Lim, LP ;
Weinstein, EG ;
Bartel, DP .
SCIENCE, 2001, 294 (5543) :858-862
[40]   An extensive class of small RNAs in Caenorhabditis elegans [J].
Lee, RC ;
Ambros, V .
SCIENCE, 2001, 294 (5543) :862-864
1234567