Synthesis, crystal structure, spectroscopic and biological properties of mixed ligand complexes of cadmium(II), cobalt(II) and manganese(II) valproate with 1,10-phenanthroline and imidazole

被引：26

作者：

Tabrizi, Leila ^{[1
,2
]}

McArdle, Patrick ^{[2
]}

Ektefan, Mehdi ^{[1
]}

Chiniforoshan, Hossein ^{[1
]}

机构：

[1] Isfahan Univ Technol, Dept Chem, Esfahan 8415683111, Iran

[2] Natl Univ Ireland Galway, Sch Chem, Galway, Ireland

来源：

INORGANICA CHIMICA ACTA | 2016年 / 439卷

关键词：

Sodium valproate; Metal complexes; Crystal structures; Anti-bacterial activity; Cytotoxicity; ANTICONVULSANT DRUG VALPROATE; IN-VITRO CYTOTOXICITY; PALLADIUM(II) COMPLEXES; COPPER(II) COMPLEXES; SODIUM VALPROATE; DNA; ADDUCTS; BINDING; ACID;

D O I：

10.1016/j.ica.2015.10.015

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Metal complexes of the type [Cd(valp)(2)(imidazole)(2)], 1, [Cd(valp)(2)(phen)H2O], 2 [Co(valp)(2) (imidazole)(2)], 3, [Co(valp)(2)(phen)H2O], 4 and [Mn(valp)(2)(phen)H2O], 5 (valp: sodium valproate, phen: 1,10-phenanthroline) have been synthesized and characterized. The geometry of the complexes 1-5 was established by single crystal X-ray diffraction. Evaluation of cytotoxic activity of the complexes 15 against HeLa, Hep-G2, A2780, LS-174, B16, MS1 and MRC-5 cell lines proved that complexes 1 and 3 exhibited cytotoxic specificity and a significant cancer cell inhibitory rate compared to complexes 2, 4 and 5. The complexes were also evaluated for their anti-bacterial activity using in vitro agar diffusion method. Two Gram-positive (Staphylococcus aureus and Bacillus subtilis) and three Gram-negative (Escherichia coli, Salmonella typhi and Pseudomonas aeruginosa) species of bacteria were used for testing anti-bacterial activities. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：138 / 144

页数：7

共 40 条

[1] Synthesis, crystal structure, spectroscopic and biological properties of mixed ligand complexes of zinc(II) valproate with 1,10-phenanthroline and 2-aminomethylpyridine [J].