Sexual differentiation of motivation: A novel mechanism?

被引：87
作者：
Becker, Jill B. [1 ,2 ]
机构：
[1] Univ Michigan, Dept Psychol, Mol & Behav Neurosci Inst, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Dept Psychiat, Neurosci Program, Reprod Sci Program, Ann Arbor, MI 48109 USA
来源：
HORMONES AND BEHAVIOR | 2009年 / 55卷 / 05期
关键词：
Sexual motivation; Drug abuse; Sex differences; Nucleus accumbens; Striatum; Dopamine; Maternal behavior; CONDITIONED PLACE PREFERENCE; SELF-ADMINISTERED COCAINE; INCREASES DOPAMINE TRANSMISSION; MEMBRANE ESTROGEN-RECEPTORS; MALE-FEMALE DIFFERENCES; NUCLEUS-ACCUMBENS; STRIATAL DOPAMINE; BEHAVIORAL SENSITIZATION; D-AMPHETAMINE; MENSTRUAL-CYCLE;
D O I：
10.1016/j.yhbeh.2009.03.014
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Sex differences in motivation are apparent for the motivation to engage in sexual behavior, the motivation to take drugs of abuse, and the motivation to engage in parental behavior. In both males and females there is an increase in NAcc DA associated with motivated behaviors. Here it proposed that sex differences in the regulation of DA activity in the ascending mesolimbic projections may underlie sex differences in motivation. In particular, sex differences in the neuroendocrine regulation of this brain system play a role in the expression of sex differences in motivated behaviors. Here it is proposed that sexual differentiation of motivation is mediated, at least in part, by a novel mechanism in which ovarian hormones secreted at puberty in the female actively feminize the DA system. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：646 / 654
页数：9
相关论文
共 157 条
[1]   Nucleus accumbens lesions decrease sensitivity to rapid changes in the delay to reinforcement [J].
Acheson, Ashley ;
Farrar, Andrew M. ;
Patak, Michele ;
Hausknecht, Kathryn A. ;
Kieres, Artur K. ;
Choi, Seulgi ;
de Wit, Harriet ;
Richards, Jerry B. .
BEHAVIOURAL BRAIN RESEARCH, 2006, 173 (02) :217-228
[2]  
Adler N T, 1974, Adv Behav Biol, V11, P259
[3]  
Adler N. T., 1978, Biological determinants of sexual behaviour., P657
[4]   EFFECTS OF MALES COPULATORY BEHAVIOR ON SUCCESSFUL PREGNANCY OF FEMALE RAT [J].
ADLER, NT .
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 1969, 69 (4P1) :613-&
[5]   ASCENDING MONOAMINE NEURONS TO TELENCEPHALON AND DIENCEPHALON [J].
ANDEN, NE ;
DAHLSTROM, A ;
FUXE, K ;
LARSSON, K ;
OLSON, L ;
UNGERSTEDT, U .
ACTA PHYSIOLOGICA SCANDINAVICA, 1966, 67 (3-4) :313-+
[6]   Sex differences in dopamine receptor overproduction and elimination [J].
Andersen, SL ;
Rutstein, M ;
Benzo, JM ;
Hostetter, JC ;
Teicher, MH .
NEUROREPORT, 1997, 8 (06) :1495-1498
[7]   Pubertal changes in gonadal hormones do not underlie adolescent dopamine receptor overproduction [J].
Andersen, SL ;
Thompson, AP ;
Krenzel, E ;
Teicher, MH .
PSYCHONEUROENDOCRINOLOGY, 2002, 27 (06) :683-691
[8]   Gender differences in stress reactivity among cocaine-dependent individuals [J].
Back, SE ;
Brady, KT ;
Jackson, JL ;
Salstrom, S ;
Zinzow, H .
PSYCHOPHARMACOLOGY, 2005, 180 (01) :169-176
[9]   Adolescents differ from adults in cocaine conditioned place preference and cocaine-induced dopamine in the nucleus accumbens septi [J].
Badanich, Kimberly A. ;
Adler, Kristopher J. ;
Kirstein, Cheryl L. .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2006, 550 (1-3) :95-106
[10]   Role for estradiol in female-typical brain and behavioral sexual differentiation [J].
Bakker, Julie ;
Baum, Michael J. .
FRONTIERS IN NEUROENDOCRINOLOGY, 2008, 29 (01) :1-16
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