Memory and Orientation in the Logopenic and Nonfluent Subtypes of Primary Progressive Aphasia

被引：19
作者：
Flanagan, Emma C. [1 ]
Tu, Sicong [1 ,2 ,3 ]
Ahmed, Samrah [4 ]
Hodges, John R. [1 ,2 ,3 ]
Hornberger, Michael [1 ,2 ,3 ,5 ]
机构：
[1] Neurosci Res Australia, Sydney, NSW, Australia
[2] Univ New S Wales, Sch Med Sci, Sydney, NSW 2052, Australia
[3] Australian Res Council Ctr Excellence Cognit & It, Sydney, NSW, Australia
[4] Univ Oxford, Nuffield Dept Clin Neurosci, Oxford, England
[5] Univ Cambridge, Dept Clin Neurosci, Cambridge, England
来源：
JOURNAL OF ALZHEIMERS DISEASE | 2014年 / 40卷 / 01期
关键词：
Memory; orientation; PiB; PPA; lv-PPA; na-PPA; DIAGNOSIS; CRITERIA; DEMENTIA; DISEASE; SPEECH;
D O I：
10.3233/JAD-131448
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Memory and orientation were investigated as predictors of underlying Alzheimer's disease (AD) pathology in patients with logopenic (lv) and non-fluent (na) variants of primary progressive aphasia (PPA). Memory and orientation scores from Addenbrooke's Cognitive Examination were compared between 26 lv-PPA, 29 na-PPA, 59 AD, and 90 controls using analysis of variance. Forty-five patients underwent Pittsburgh compound B (PiB) positron emission tomography scans. Patients with lv-PPA performed poorer on memory and orientation than na-PPA and did not differ from the AD group. Post-hoc analysis on the PiB-scanned subgroup corroborated these results. Memory and orientation profiles may supplement language assessment in identifying patients with AD pathology.
引用
收藏
页码：33 / 36
页数：4
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