L-2-hydroxyglutaric aciduria and brain malignant tumors - A predisposing condition?

被引：92

作者：

Moroni, I

Bugiani, M

D'Incerti, L

Maccagnano, C

Rimoldi, M

Bissola, L

Pollo, B

Finocchiaro, G

Uziel, G

机构：

[1] Natl Neurol Inst C Besta, Dept Child Neurol, I-20133 Milan, Italy

[2] Natl Neurol Inst C Besta, Dept Neuroradiol, I-20133 Milan, Italy

[3] Natl Neurol Inst C Besta, Dept Biochem & Genet, I-20133 Milan, Italy

[4] Natl Neurol Inst C Besta, Dept Neuropathol, I-20133 Milan, Italy

来源：

NEUROLOGY | 2004年 / 62卷 / 10期

关键词：

D O I：

10.1212/01.WNL.0000125335.21381.87

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

L-2-hydroxyglutaric aciduria is a rare metabolic encephalopathy displaying a subcortical leukoencephalopathy on MRI. Diagnosis rests on detection of an abnormal accumulation of L-2-hydroxyglutaric acid in body fluids. The authors report on four patients who developed a malignant brain tumor during the course of the disease. This association points to a possible role of L-2-hydroxyglutaric aciduria in predisposing to brain tumorigenesis.

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页码：1882 / 1884

页数：3

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