Dynamin as a mover and pincher during cell migration and invasion

被引：103
作者：
Kruchten, Anne E.
McNiven, Mark A.
机构：
[1] Mayo Clin, Coll Med, Ctr Basic Res Digest Dis, Rochester, MN 55905 USA
[2] Mayo Clin, Coll Med, Dept Biochem & Mol Biol, Rochester, MN 55905 USA
来源：
JOURNAL OF CELL SCIENCE | 2006年 / 119卷 / 09期
关键词：
dynamin; cell motility; migration; invasion;
D O I：
10.1242/jcs.02963
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The large GTPase dynamin, long known for its role in endocytosis, has most recently been implicated as a facilitator of cell migration and invasion. Recent observations link dynamin to the cycle of membrane expansion and retraction essential for cell motility. Its role in actin polymerization, membrane deformation and vesiculation, and focal adhesion dynamics are all important for this process, and the new findings provide exciting directions for studies of this ubiquitous and diverse protein family.
引用
收藏
页码：1683 / 1690
页数：8
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