Genetic stability of pluripotent stem cells during anti-cancer therapies

被引:8
作者
Suchorska, Wiktoria Maria [1 ,2 ,3 ]
Augustyniak, Ewelina [1 ,2 ]
Lukjanow, Magdalena [1 ]
机构
[1] Greater Poland Canc Ctr, Radiobiol Lab, 15 Garbary St, PL-61866 Poznan, Poland
[2] Med Univ Warsaw, Postgrad Sch Mol Med, PL-20091 Warsaw, Poland
[3] Poznan Univ Med Sci, Dept Electroradiol, PL-61866 Poznan, Poland
关键词
pluripotent stem cells; DNA repair; genetic stability; DNA damage response; ionizing radiation; chemotherapeutics; DNA-DAMAGE RESPONSE; NUCLEOTIDE EXCISION-REPAIR; HOMOLOGOUS RECOMBINATION; IONIZING-RADIATION; STRAND BREAKS; APOPTOSIS; CANCER; DEATH; END; DIFFERENTIATION;
D O I
10.3892/etm.2016.2993
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Regenerative medicine is a rapidly growing field that holds promise for the treatment of many currently unresponsive diseases. Stem cells (SCs) are undifferentiated cells with long-term self-renewal potential and the capacity to develop into specialized cells. SC-based therapies constitute a novel and promising concept in regenerative medicine. Radiotherapy is the most frequently used method in the adjuvant treatment of tumorous alterations. In the future, the usage of SCs in regenerative medicine will be affected by their regular and inevitable exposure to ionizing radiation (IR). This phenomenon will be observed during treatment as well as diagnosis. The issue of the genetic stability of SCs and cells differentiated from SCs is crucial in the context of the application of these cells in clinical practice. This review examines current knowledge concerning the DNA repair mechanisms (base excision repair, nucleotide excision repair, mismatch repair, homologous recombination and non-homologous end-joining) of SCs in response to the harmful effects of genotoxic agents such as IR and chemotherapeutics.
引用
收藏
页码:695 / 702
页数:8
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