Helicobacter pylori infection, chronic corpus atrophic gastritis and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort: A nested case-control study

被引：41

作者：

Huang, Jiaqi ^{[1
]}

Zagai, Ulrika ^{[1
]}

Hallmans, Goran ^{[2
]}

Nyren, Olof ^{[1
]}

Engstrand, Lars ^{[3
]}

Stolzenberg-Solomon, Rachael ^{[4
]}

Duell, Eric J. ^{[5
]}

Overvad, Kim ^{[6
]}

Katzke, Verena A. ^{[7
]}

Kaaks, Rudolf ^{[7
]}

Jenab, Mazda ^{[8
]}

Park, Jin Young ^{[8
]}

Murillo, Raul ^{[8
]}

Trichopoulou, Antonia ^{[9
,10
]}

Lagiou, Pagona ^{[9
,10
,11
]}

Bamia, Christina ^{[9
,10
]}

Bradbury, Kathryn E. ^{[12
]}

Riboli, Elio ^{[13
]}

Aune, Dagfinn ^{[13
]}

Tsilidis, Konstantinos K. ^{[13
,24
]}

Capella, Gabriel ^{[14
]}

Agudo, Antonio ^{[15
]}

Krogh, Vittorio ^{[16
]}

Palli, Domenico ^{[17
]}

Panico, Salvatore ^{[18
]}

Weiderpass, Elisabete ^{[1
,19
,20
,21
]}

Tjonneland, Anne ^{[22
]}

Olsen, Anja ^{[22
]}

Martinez, Begona ^{[23
]}

Redondo-Sanchez, Daniel ^{[23
,26
,40
]}

Chirlaque, Maria-Dolores ^{[25
,26
,27
]}

Peeters, Petra Hm ^{[28
]}

Regner, Sara ^{[29
]}

Lindkvist, Bjorn ^{[30
]}

Naccarati, Alessio ^{[31
]}

Ardanaz, Eva ^{[26
,32
,33
]}

Larranaga, Nerea ^{[26
]}

Boutron-Ruault, Marie-Christine ^{[34
,35
,36
]}

Rebours, Vinciane ^{[37
]}

Barre, Amelie ^{[38
,39
]}

Bueno-de-Mesquita, H. B ^{[41
,42
,43
,44
]}

Ye, Weimin ^{[1
,45
]}

机构：

[1] Karolinska Inst, Dept Med Epidemiol & Biostat, Solna, Sweden

[2] Umea Univ, Dept Publ Hlth & Clin Nutr, Umea, Sweden

[3] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden

[4] NCI, Metab Epidemiol Branch, Div Canc Epidemiol & Genet, NIH, Rockville, MD USA

[5] Catalan Inst Oncol ICO IDIBELL, Unit Nutr & Canc, Canc Epidemiol Res Program, Barcelona, Spain

[6] Aarhus Univ, Epidemiol Sect, Dept Publ Hlth, Aarhus, Denmark

[7] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[8] Int Agcy Res Canc, Sect Nutr & Metab, Sect Early Detect & Prevent, Prevent & Implementat Grp, Lyon, France

[9] Hellen Hlth Fdn, Athens, Greece

[10] Natl & Kapodistrian Univ Athens, WHO Collaborating Ctr Nutr & Hlth, Sch Med, Unit Nutr Epidemiol & Nutr Publ Hlth,Dept Hyg Epi, Athens, Greece

[11] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

[12] Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England

[13] Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

[14] IDIBELL Catalan Inst Oncol, Translat Res Lab, Barcelona, Spain

[15] Catalan Inst Oncol IDIBELL, Canc Epidemiol Res Program, Unit Nutr & Canc, Barcelona, Spain

[16] Fdn IRCCS Ist Nazl Tumori, Epidemiol & Prevent Unit, Milan, Italy

[17] Canc Res & Prevent Inst ISPO, Canc Risk Factors & Life Style Epidemiol Unit, Florence, Italy

[18] Dipartimento Med Clin & Chirurg Federico II, Naples, Italy

[19] Arctic Univ Norway, Univ Tromso, Dept Community Med, Tromso, Norway

[20] Inst Populat Based Canc Res, Canc Registry Norway, Dept Res, Oslo, Norway

[21] Folkhalsan Res Ctr, Genet Epidemiol Grp, Helsinki, Finland

[22] Danish Canc Soc, Res Ctr, Copenhagen, Denmark

[23] Inst Invest Biosanitaria Ibs, Andalusian Sch Publ Hlth, Granada, Spain

[24] Univ Ioannina, Sch Med, Dept Hyg & Epidemiol, Ioannina, Greece

[25] IMIB Arrixaca, Reg Hlth Council, Dept Epidemiol, Murcia, Spain

[26] CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain

[27] Univ Murcia, Dept Hlth & Social Sci, Murcia, Spain

[28] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Dept Epidemiol, Utrecht, Netherlands

[29] Lund Univ, Inst Clin Sci Malmo, Dept Surg, Malmo, Sweden

[30] Sahlgrens Univ Hosp, Dept Med, Gothenburg, Sweden

[31] Human Genet Fdn, Mol & Genet Epidemiol Unit, Turin, Italy

[32] Navarra Publ Hlth Inst, Pamplona, Spain

[33] Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain

[34] Ctr Res Epidemiol & Populat Hlth CESP, Hormones & Womens Hlth Team, INSERM, U1018,Nutr, F-94805 Villejuif, France

[35] Univ Paris Sud, UMRS 1018, F-94805 Villejuif, France

[36] Inst Gustave Roussy, F-94805 Villejuif, France

[37] Univ Paris 07, Beaujon Hosp, Dept Gastroenterol & Pancreatol, Clichy, France

[38] Univ Paris Sud, Le Kremlin Bicetre, France

[39] CHU Bicetre, Hop Univ Paris Sud, AP HP, Gastroenterol Unit, Le Kremlin Bicetre, France

[40] Univ Granada, Hosp Univ Granada, Inst Invest Biosanitaria Ibs, Escuela Andaluza Salud Publ, Granada, Spain

[41] Natl Inst Publ Hlth & Environm RIVM, Dept Determinants Chron Dis DCD, Bilthoven, Netherlands

[42] Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[43] Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

[44] Univ Malaya, Fac Med, Dept Social & Prevent Med, Kuala Lumpur, Malaysia

[45] Umea Univ, Med Biobank, Umea, Sweden

来源：

INTERNATIONAL JOURNAL OF CANCER | 2017年 / 140卷 / 08期

基金：

英国医学研究理事会;

关键词：

H. pylori infection; chronic corpus atrophic gastritis; pancreatic cancer risk; nested case-control study; EPIC cohort; ABO BLOOD-GROUP; SEROPOSITIVITY; CAGA; EPIDEMIOLOGY; METAANALYSIS; ASSOCIATION; POPULATION; STATISTICS;

D O I：

10.1002/ijc.30590

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The association between H. pylori infection and pancreatic cancer risk remains controversial. We conducted a nested case-control study with 448 pancreatic cancer cases and their individually matched control subjects, based on the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, to determine whether there was an altered pancreatic cancer risk associated with H. pylori infection and chronic corpus atrophic gastritis. Conditional logistic regression models were applied to calculate odds ratios (ORs) and corresponding 95% confidence intervals (CIs), adjusted for matching factors and other potential confounders. Our results showed that pancreatic cancer risk was neither associated with H. pylori seropositivity (OR = 0.96; 95% CI: 0.70, 1.31) nor CagA seropositivity (OR = 1.07; 95% CI: 0.77, 1.48). We also did not find any excess risk among individuals seropositive for H. pylori but seronegative for CagA, compared with the group seronegative for both antibodies (OR = 0.94; 95% CI: 0.63, 1.38). However, we found that chronic corpus atrophic gastritis was non-significantly associated with an increased pancreatic cancer risk (OR = 1.35; 95% CI: 0.77, 2.37), and although based on small numbers, the excess risk was particularly marked among individuals seronegative for both H. pylori and CagA (OR = 5.66; 95% CI: 1.59, 20.19, p value for interaction < 0.01). Our findings provided evidence supporting the null association between H. pylori infection and pancreatic cancer risk in western European populations. However, the suggested association between chronic corpus atrophic gastritis and pancreatic cancer risk warrants independent verification in future studies, and, if confirmed, further studies on the underlying mechanisms.

引用

页码：1727 / 1735

页数：9

共 50 条

[31] Statins and pancreatic cancer risk: a nested case-control study [J].

Bradley, Marie C. ;

Hughes, Carmel M. ;

Cantwell, Marie M. ;

Murray, Liam J. .

CANCER CAUSES & CONTROL, 2010, 21 (12) :2093-2100

[32] Coffee and tea consumption and risk of pre- and postmenopausal breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study [J].

Bhoo-Pathy, Nirmala ;

Peeters, Petra H. M. ;

Uiterwaal, Cuno S. P. M. ;

Bueno-de-Mesquita, H. Bas ;

Bulgiba, Awang M. ;

Bech, Bodil Hammer ;

Overvad, Kim ;

Tjonneland, Anne ;

Olsen, Anja ;

Clavel-Chapelon, Francoise ;

Fagherazzi, Guy ;

Perquier, Florence ;

Teucher, Birgit ;

Kaaks, Rudolf ;

Schuetze, Madlen ;

Boeing, Heiner ;

Lagiou, Pagona ;

Orfanos, Philippos ;

Trichopoulou, Antonia ;

Agnoli, Claudia ;

Mattiello, Amalia ;

Palli, Domenico ;

Tumino, Rosario ;

Sacerdote, Carlotta ;

van Duijnhoven, Franzel J. B. ;

Braaten, Tonje ;

Lund, Eiliv ;

Skeie, Guri ;

Redondo, Maria-Luisa ;

Buckland, Genevieve ;

Sanchez Perez, Maria Jose ;

Chirlaque, Maria-Dolores ;

Ardanaz, Eva ;

Amiano, Pilar ;

Wirfalt, Elisabet ;

Wallstrom, Peter ;

Johansson, Ingegerd ;

Nilsson, Lena Maria ;

Khaw, Kay-Tee ;

Wareham, Nick ;

Allen, Naomi E. ;

Key, Timothy J. ;

Rinaldi, Sabina ;

Romieu, Isabelle ;

Gallo, Valentina ;

Riboli, Elio ;

van Gils, Carla H. .

BREAST CANCER RESEARCH, 2015, 17

[33] Helicobacter pylori infection, chronic atrophic gastritis and major cardiovascular events: A population-based cohort study [J].

Schoettker, Ben ;

Adamu, Mariam A. ;

Weck, Melanie N. ;

Mueller, Heiko ;

Brenner, Hermann .

ATHEROSCLEROSIS, 2012, 220 (02) :569-574

[34] Coffee consumption and risk of chronic disease in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Germany study [J].

Floegel, Anna ;

Pischon, Tobias ;

Bergmann, Manuela M. ;

Teucher, Birgit ;

Kaaks, Rudolf ;

Boeing, Heiner .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 2012, 95 (04) :901-908

[35] Helicobacter Pylori Infection and Risk of Death From Cardiovascular Disease Among the Japanese Population: a Nested Case-Control Study within the JACC Study [J].

Lin, Yingsong ;

Obata, Yuki ;

Kikuchi, Shogo ;

Tamakoshi, Akiko ;

Iso, Hiroyuki .

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 2015, 22 (11) :1207-1213

[36] Analysis of garlic intake on atrophic gastritis risk in different infectious states of Helicobacter pylori in a case-control study [J].

Wu, Jianjun ;

Zhang, Jia ;

Jin, Lan ;

Wei, Xingmin ;

Liu, Yuqin .

SCIENTIFIC REPORTS, 2025, 15 (01)

[37] Biomarkers of inflammation and breast cancer risk: a case-control study nested in the EPIC-Varese cohort [J].

Agnoli, Claudia ;

Grioni, Sara ;

Pala, Valeria ;

Allione, Alessandra ;

Matullo, Giuseppe ;

Di Gaetano, Cornelia ;

Tagliabue, Giovanna ;

Sieri, Sabina ;

Krogh, Vittorio .

SCIENTIFIC REPORTS, 2017, 7

[38] Circulating C-Reactive Protein Concentrations and Risks of Colon and Rectal Cancer: A Nested Case-Control Study Within the European Prospective Investigation into Cancer and Nutrition [J].

Aleksandrova, Krasimira ;

Jenab, Mazda ;

Boeing, Heiner ;

Jansen, Eugene ;

Bueno-de-Mesquita, H. Bas ;

Rinaldi, Sabina ;

Riboli, Elio ;

Overvad, Kim ;

Dahm, Christina C. ;

Olsen, Anja ;

Tjonneland, Anne ;

Boutron-Ruault, Marie-Christine ;

Clavel-Chapelon, Francoise ;

Morois, Sophie ;

Palli, Domenico ;

Krogh, Vittorio ;

Tumino, Rosario ;

Vineis, Paolo ;

Panico, Salvatore ;

Kaaks, Rudolf ;

Rohrmann, Sabine ;

Trichopoulou, Antonia ;

Lagiou, Pagona ;

Trichopoulos, Dimitrios ;

van Duijnhoven, Fraenzel J. B. ;

Leufkens, Anke M. ;

Peeters, Petra H. ;

Rodriguez, Laudina ;

Bonet, Catalina ;

Sanchez, Maria-Jose ;

Dorronsoro, Miren ;

Navarro, Carmen ;

Barricarte, Aurelio ;

Palmqvist, Richard ;

Hallmans, Goran ;

Khaw, Kay-Tee ;

Wareham, Nicholas ;

Allen, Naomi E. ;

Spencer, Elizabeth ;

Romaguera, Dora ;

Norat, Teresa ;

Pischon, Tobias .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2010, 172 (04) :407-418

[39] Coffee and tea intake and risk of brain tumors in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study [J].

Michaud, Dominique S. ;

Gallo, Valentina ;

Schlehofer, Brigitte ;

Tjonneland, Anne ;

Olsen, Anja ;

Overvad, Kim ;

Dahm, Christina C. ;

Teucher, Birgit ;

Lukanova, Annekatrin ;

Boeing, Heiner ;

Schutze, Madlen ;

Trichopoulou, Antonia ;

Lagiou, Pagona ;

Kyrozis, Andreas ;

Sacerdote, Carlotta ;

Krogh, Vittorio ;

Masala, Giovanna ;

Tumino, Rosario ;

Mattiello, Amalia ;

de Mesquita, H. Bas Bueno ;

Ros, Martine M. ;

Peeters, Petra H. M. ;

van Gils, Carla H. ;

Skeie, Guri ;

Engeset, Dagrun ;

Parr, Christine L. ;

Ardanaz, Eva ;

Chirlaque, Maria-Dolores ;

Dorronsoto, Miren ;

Jose Sanchez, Maria ;

Arguelles, Marcial ;

Jakszyn, Paula ;

Nilsson, Lena M. ;

Melin, Beatrice S. ;

Manjer, Jonas ;

Wirfalt, Elisabet ;

Khaw, Kay-Tee ;

Wareham, Nick ;

Allen, Naomi E. ;

Key, Timothy J. ;

Romieu, Isabelle ;

Vinets, Paolo ;

Riboli, Elio .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 2010, 92 (05) :1145-1150

[40] Prospective study of Helicobacter pylori antigens and gastric noncardia cancer risk in the nutrition intervention trial cohort [J].

Murphy, Gwen ;

Freedman, Neal D. ;

Michel, Angelika ;

Fan, Jin-Hu ;

Taylor, Philip R. ;

Pawlita, Michael ;

Qiao, You-Lin ;

Zhang, Han ;

Yu, Kai ;

Abnet, Christian C. ;

Dawsey, Sanford M. .

INTERNATIONAL JOURNAL OF CANCER, 2015, 137 (08) :1938-1946

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