Shelled sweet corn kernels are prone to microbial contamination, making it highly perishable and unsafe. In freshly shelled kernels, total aerobic plate count, yeast mold count and presumptive coliforms were similar to 8, 7 and 4 log cfu/g, respectively. IMViC (indole-methyl red-Voges-Proskauer [VP]-citrate) analysis confirmed the presence of opportunistic pathogens such as Escherichia coli and Enterobacter aerogenes. A combination process including NaOCl wash (200 ppm), hot water blanching (60C), followed by gamma irradiation (5 kGy) reduced the microbial load to below detectable level (<2 log cfu/g) and maintained it within permissible level up to 30 days at 4C. However, these treatments alone were not found to be very effective. Total sugars (similar to 1 g/100 g), reducing sugar (similar to 0.58 g/100 g), protein (similar to 0.6 g/100 g), phenolics, flavonoids, antioxidant capacity (33%), antimutagenic potential (43%), physical properties and sensory qualities of combination processed samples during storage were found to be similar as those of fresh samples (control). Developed combination process ensured safety and extended the shelf life of kernels.