The immunobiology of Acanthamoeba keratitis

被引:46
作者
Clarke, Daniel W. [1 ]
Niederkorn, Jerry Y. [1 ]
机构
[1] Univ Texas, SW Med Ctr, Dept Ophthalmol & Microbiol, Dallas, TX 75390 USA
关键词
amoeba; keratitis; cornea; immunology;
D O I
10.1016/j.micinf.2005.12.009
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Acanthamoeba spp. are free-living amoebae that cause Acanthamoeba keratitis, a blinding corneal infection. The innate immune apparatus is crucial for the resolution of the disease. With the exception of mucosal antibody, elements of the adaptive immune system fail to prevent infection or contribute to its resolution in experimental animals. (c) 2006 Elsevier SAS. All fights reserved.
引用
收藏
页码:1400 / 1405
页数:6
相关论文
共 50 条
[1]  
Aksozek A, 2002, J PARASITOL, V88, P621, DOI 10.1645/0022-3395(2002)088[0621:ROACCT]2.0.CO
[2]  
2
[3]   Role of contact lens wear, bacterial flora, and mannose-induced pathogenic protease in the pathogenesis of amoebic keratitis [J].
Alizadeh, H ;
Neelam, S ;
Hurt, M ;
Niederkorn, JY .
INFECTION AND IMMUNITY, 2005, 73 (02) :1061-1068
[4]   Tear IgA and serum IgG antibodies against Acanthamoeba in patients with Acanthamoeba keratitis [J].
Alizadeh, H ;
Apte, S ;
El-Agha, MSH ;
Li, L ;
Hurt, M ;
Howard, K ;
Cavanagh, HD ;
McCulley, JP ;
Niederkorn, JY .
CORNEA, 2001, 20 (06) :622-627
[5]  
ALIZADEH H, 1995, CORNEA, V14, P180, DOI 10.1097/00003226-199503000-00012
[6]  
Alizadeh H., 1996, OCULAR INFECT IMMUNI, P1062
[7]   Neutrophil depletion during Toxoplasma gondii infection leads to impaired immunity and lethal systemic pathology [J].
Bliss, SK ;
Gavrilescu, CL ;
Alcaraz, A ;
Denkers, EY .
INFECTION AND IMMUNITY, 2001, 69 (08) :4898-4905
[8]  
BORA NS, 1993, INVEST OPHTH VIS SCI, V34, P3579
[9]  
CERVA L, 1989, Journal of Hygiene Epidemiology Microbiology and Immunology (Prague), V33, P99
[10]   Failure of Acanthamoeba castellanii to produce intraocular infections [J].
Clarke, DW ;
Alizadeh, H ;
Niederkorn, JY .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2005, 46 (07) :2472-2478