Flavonoids with Gastroprotective Activity

被引：252
作者：
de Lira Mota, Kelly Samara [1 ]
Nunes Dias, Guilherme Eduardo [1 ]
Ferreira Pinto, Meri Emili [1 ]
Luiz-Ferreira, Anderson [2 ]
Monteiro Souza-Brito, Alba Regina [2 ]
Hiruma-Lima, Clelia Akiko [3 ]
Barbosa-Filho, Jose Maria [1 ]
Batista, Leonia Maria [1 ]
机构：
[1] Univ Fed Paraiba, Lab Tecnol Farmaceut Prof Delby Fernandes Medeiro, BR-58051970 Joao Pessoa, Paraiba, Brazil
[2] Univ Estadual Campinas, UNICAMP, Lab Prod Nat, BR-13083970 Campinas, SP, Brazil
[3] Univ Nacl Estadual Sao Paulo, Inst Biosci, Dept Fisiol, BR-18618000 Botucatu, SP, Brazil
来源：
MOLECULES | 2009年 / 14卷 / 03期
关键词：
Flavonoids; Gastroprotective activity; Peptic ulcers; Natural products; INDUCED GASTRIC-LESIONS; ANTIULCER ACTIVITY; ISOPRENYL FLAVONOIDS; GASTROINTESTINAL-TRACT; DIETARY FLAVONOIDS; ULCER; QUERCETIN; ETHANOL; RATS; ANTIOXIDANTS;
D O I：
10.3390/molecules14030979
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Peptic ulcers are a common disorder of the entire gastrointestinal tract that occurs mainly in the stomach and the proximal duodenum. This disease is multifactorial and its treatment faces great difficulties due to the limited effectiveness and severe side effects of the currently available drugs. The use of natural products for the prevention and treatment of different pathologies is continuously expanding throughout the world. This is particularly true with regards to flavonoids, which represent a highly diverse class of secondary metabolites with potentially beneficial human health effects that is widely distributed in the plant kingdom and currently consumed in large amounts in the diet. They display several pharmacological properties in the gastroprotective area, acting as anti-secretory, cytoprotective and antioxidant agents. Besides their action as gastroprotectives, flavonoids also act in healing of gastric ulcers and additionally these polyphenolic compounds can be new alternatives for suppression or modulation of peptic ulcers associated with H. pylori. In this review, we have summarized the literature on ninety-five flavonoids with varying degrees of antiulcerogenic activity, confirming that flavonoids have a therapeutic potential for the more effective treatment of peptic ulcers.
引用
收藏
页码：979 / 1012
页数：34
相关论文
共 104 条
  • [1] [Anonymous], 1988, PHYTOTHER RES, DOI DOI 10.1002/PTR.2650020208
  • [2] BALINT GA, 1985, STUD ORG CHEM, V23, P453
  • [3] Bandyopadhyay Debashis, 2001, Current Molecular Medicine (Hilversum), V1, P501, DOI 10.2174/1566524013363483
  • [4] Bandyopadhyay Debashis, 2002, Indian Journal of Experimental Biology, V40, P693
  • [5] BARNAULOV O D, 1985, Rastitel'nye Resursy, V21, P85
  • [6] BARNAULOV OD, 1984, KHIM FARM ZH+, V18, P935
  • [7] BARNAULOV OD, 1983, KHIM FARM ZH+, V17, P946
  • [8] BARNAULOV OD, 1982, KHIM FARM ZH+, V16, P300
  • [9] Beecher GR, 2003, J NUTR, V133, p3248S
  • [10] BEIL W, 1995, ARZNEIMITTELFORSCH, V45-1, P697
12345678910