Superoxide radical trapping and spin adduct decay of 5-tert-butoxycarbonyl-5-methyl-1-pyrroline N-oxide (BocMPO):: kinetics and theoretical analysis

被引：62

作者：

Villamena, FA

Zweier, JL ^{[1
]}

机构：

[1] Johns Hopkins Med Inst, Dept Med, Div Cardiol, Mol & Cellular Biophys Labs, Baltimore, MD 21224 USA

[2] Johns Hopkins Med Inst, Electron Paramagnet Resonance Ctr, Baltimore, MD 21224 USA

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 | 2002年 / 07期

关键词：

D O I：

10.1039/b201734b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Spin-trapping of oxygen-centered radicals such as superoxide radical is increasingly becoming important in the study of biological oxidations. Superoxide spin-trapping and decay kinetics in aqueous media of the new solid nitrone 5-tert-butoxycarbonyl-5-methyl-1-pyrroline N-oxide (BocMPO) are reported and compared to those of 5,5-dimethyl-1-pyrroline N-oxide (DMPO) and 5-diethoxyphosphoryl-5-methyl-1-pyrroline N-oxide (DEPMPO). Superoxide spin-trapping by BocMPO is significantly slower than that by DEPMPO and DMPO, and the half-life of BocMPO-superoxide adduct is shorter than that of DEPMPO-superoxide adduct. The BocMPO spin-trapping ability and stability of its superoxide adducts are rationalized based on theoretical calculations.

引用

页码：1340 / 1344

页数：5

共 26 条

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