Sustained Release of Atorvastatin from Radiation-Synthesized Stimuli-Responsive Hydrogels

被引：3
|
作者：
Mohanan, A. [1 ]
Vishalakshi, B. [1 ]
Charyulu, R. N. [2 ]
Harish, N. M. [2 ]
Ganesh, S. [3 ]
机构：
[1] Mangalore Univ, Dept Postgrad Studies & Res Chem, Mangalagangotri Dk 574199, Karnataka, India
[2] NGSM Inst Pharmaceut Sci, Deralakatte Dk, Karnataka, India
[3] Mangalore Univ, Microtron Ctr, Dept Studies Phys, Mangalagangotri Dk 574199, Karnataka, India
来源：
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2013年 / 62卷 / 01期
关键词：
Diffusion controlled drug release; electron beam irradiation; stimuli responsive hydrogel; N-ISOPROPYLACRYLAMIDE; ENCAPSULATION; MICROSPHERES; NETWORK;
D O I：
10.1080/00914037.2011.641636
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
The present paper deals with the study of suitability of interpenetrating network hydrogels comprising N-isopropylacrylamide and k-carrageenan as matrix materials for the sustained release of Atorvastatin. The drug was incorporated in various gels by the active-loading technique and the in-vitro release kinetics was studied at pH 1.2 and 7.4. When the release data were analyzed as per the Korsmeyer and Peppas equation, the release exponent "n" was observed to be dependent on temperature and pH conditions, indicating the influence of release conditions on gel structure and in turn on the drug release mechanism.
引用
收藏
页码：5 / 9
页数：5
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