Physical properties of lipid bilayers from EPR spin labeling and their influence on chemical reactions in a membrane environment

被引：59

作者：

Subczynski, Witold K. ^{[1
]}

Widomska, Justyna ^{[2
]}

Feix, Jimmy B. ^{[1
]}

机构：

[1] Med Coll Wisconsin, Dept Biophys, Milwaukee, WI 53226 USA

[2] Jagiellonian Univ, Fac Biochem Biophys & Biotechnol, Dept Plant Physiol & Biochem, Krakow, Poland

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2009年 / 46卷 / 06期

基金：

美国国家卫生研究院;

关键词：

Lipid bilayer; Spin labeling; EPR; Hydrophobicity; Polarity; Fluidity; Oxygen; Nitric oxide; Free radicals; ALKYL CHAIN-LENGTH; PHOSPHATIDYLCHOLINE-CHOLESTEROL MEMBRANES; DIFFUSION-CONCENTRATION PRODUCT; OXYGEN-TRANSPORT PARAMETER; ELECTRON DOUBLE-RESONANCE; NITRIC-OXIDE; SATURATION-RECOVERY; MOLECULAR-ORGANIZATION; VERTICAL FLUCTUATIONS; PHOSPHOLIPID-BILAYERS;

D O I：

10.1016/j.freeradbiomed.2008.11.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The influence of a variety of microenvironmental factors oil the inherent reactivity of membrane-located reagents is poorly understood. A goal of this review is to provide detailed profiles of membrane properties, including hydrophobicity, oxygen and nitric oxide solubility and diffusion rates, bilayer penetration of metal ions and metal-ion complexes, and membrane order and fluidity, that can be obtained with EPR spin-labeling methods. These properties can drastically vary with membrane composition, membrane depth, and membrane domain formation, influencing the fate of chemical reactions that occur in a lipid bilayer environment. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：707 / 718

页数：12

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