Increased phosphorylation of caveolin-1 in the spinal cord of Lewis rats with experimental autoimmune encephalomyelitis

被引：19

作者：

Kim, Heechul

Ahm, Meejung

Lee, Jeeyoung

Moon, Changjong

Matsumoto, Yoh

Koh, Chang Sung

Shin, Taekyun ^{[1
]}

机构：

[1] Cheju Natl Univ, Dept Vet Med, Cheju 690756, South Korea

[2] Tokyo Metropolitan Inst Neurosci, Dept Mol Neuropathol, Fuchu, Tokyo 183, Japan

[3] Shinshu Univ, Sch Hlth Sci, Dept Biomed Lab Sci, Matsumoto, Nagano 3908621, Japan

来源：

NEUROSCIENCE LETTERS | 2006年 / 402卷 / 1-2期

基金：

新加坡国家研究基金会;

关键词：

caveolin-1; experimental autoimmune encephalomyelitis; glial cells; macrophages;

D O I：

10.1016/j.neulet.2006.04.008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The expression of phospho-specific caveolin-1 (p-caveolin-1) was analyzed in the spinal cord of Lewis rats with experimental autoimmune encephalomyelitis (EAE). Western blot analysis showed that p-caveolin-1 was constitutively expressed in normal spinal cords and that it significantly increased in the spinal cord with EAE at both early and peak stages of EAE (P < 0.05), and decreased slightly at the recovery stage of EAE. Immunohistochemistry showed that p-caveolin-1 was constitutively expressed in few vascular endothelial cells and glial cells in the spinal cords of normal rats. In EAE lesions, p-caveolin-1 was intensely immunostained in inflammatory T cells and macrophages. Therefore, we postulate that phosphorylation of caveolin-1 occurred in the inflammatory cells of EAE lesions, and that caveolin-associated cell activation is mainly associated with inflammatory cells that appear during early and peak stages of EAE. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：76 / 80

页数：5

共 16 条

[1] Tyrosine phosphorylation of caveolin 1 by oxidative stress is reversible and dependent on the c-src tyrosine kinase but not mitogen-activated protein kinase pathways in placental artery endothelial cells [J].