High-throughput screening studies of fiber-supported catalysts leading to room-temperature Suzuki coupling

被引：73

作者：

Colacot, TJ ^{[1
]}

Gore, ES ^{[1
]}

Kuber, A ^{[1
]}

机构：

[1] Johnson Matthey, Catalysts & Chem Div, W Deptford, NJ 08066 USA

来源：

ORGANOMETALLICS | 2002年 / 21卷 / 16期

关键词：

D O I：

10.1021/om020352+

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

High-throughput screening of triphenylphosphine-based polymer-supported homogeneous catalysts (e.g., FibreCat(TM)-1001) and selected Johnson Matthey Pd/C catalysts has achieved nearly quantitative conversion of activated and unactivated aryl bromides in Suzuki coupling using an ethanol-water solvent system. For more challenging substrates such as p-chloroacetophenone and 3-bromothiophene, coupling could be possible by tuning the FibreCat catalysts with t-Bu3P. These tuned catalysts (TunaCat) are air-stable.

引用

页码：3301 / 3304

页数：4

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