Sickle Cell Disease A Brief Update

被引：57

作者：

Azar, Shari ^{[1
]}

Wong, Trisha E. ^{[2
,3
]}

机构：

[1] Oregon Hlth & Sci Univ, Div Hematol & Med Oncol, Dept Med, 3181 Southwest Sam Jackson Pk Rd,Mailstop L586, Portland, OR 97239 USA

[2] Oregon Hlth & Sci Univ, Div Hematol Oncol, Dept Pediat, 3181 Southwest Sam Jackson Pk Rd,Mailstop CDRCP, Portland, OR 97239 USA

[3] Oregon Hlth & Sci Univ, Dept Pathol, Div Transfus Serv, 3181 Southwest Sam Jackson Pk Rd,Mailstop HRC9, Portland, OR 97239 USA

来源：

MEDICAL CLINICS OF NORTH AMERICA | 2017年 / 101卷 / 02期

关键词：

Sickle cell disease; Sickle cell anemia; Hemoglobinopathy; Hydroxyurea; Iron overload; Review; SILENT CEREBRAL INFARCTS; FETAL-HEMOGLOBIN; YOUNG-ADULTS; NITRIC-OXIDE; TRANSFUSION MANAGEMENT; MEDICATION ADHERENCE; CHELATION TREATMENT; PEDIATRIC-PATIENTS; CONJUGATE VACCINE; CONTROLLED-TRIAL;

D O I：

10.1016/j.mcna.2016.09.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Sickle cell disease (SCD) is an inherited monogenic disease characterized by misshapen red blood cells that causes vaso-occlusive disease, vasculopathy, and systemic inflammation. Approximately 300,000 infants are born per year with SCD globally. Acute, chronic, and acute-on-chronic complications contribute to end-organ damage and adversely affect quantity and quality of life. Hematopoietic stem cell transplantation is the only cure available today, but is not feasible for the vast majority of people suffering from SCD. Fortunately, new therapies are in late clinical trials and more are in the pipeline, offering hope for this unfortunate disease, which has increasing global burden.

引用

页码：375 / +

页数：20

共 111 条

[1]

Amado RG, 2000, SEMIN ONCOL, V27, P82

[2] Assessing cardiac and liver iron overload in chronically transfused patients with sickle cell disease [J].

Badawy, Sherif M. ;

Liem, Robert I. ;

Rigsby, Cynthia K. ;

Labotka, Richard J. ;

DeFreitas, R. Andrew ;

Thompson, Alexis A. .

BRITISH JOURNAL OF HAEMATOLOGY, 2016, 175 (04) :705-713

[3] Technology Access and Smartphone App Preferences for Medication Adherence in Adolescents and Young Adults With Sickle Cell Disease [J].

Badawy, Sherif M. ;

Thompson, Alexis A. ;

Liem, Robert I. .

PEDIATRIC BLOOD & CANCER, 2016, 63 (05) :848-852

[4] Exposure to Hydroxyurea and Pregnancy Outcomes in Patients With Sickle Cell Anemia [J].

Ballas, Samir K. ;

McCarthy, William F. ;

Guo, Nan ;

DeCastro, Laura ;

Bellevue, Rita ;

Barton, Bruce A. ;

Waclawiw, Myron A. .

JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION, 2009, 101 (10) :1046-1051

[5] Long-term treatment follow-up of children with sickle cell disease monitored with abnormal transcranial Doppler velocities [J].

Bernaudin, Francoise ;

Verlhac, Suzanne ;

Arnaud, Cecile ;

Kamdem, Annie ;

Hau, Isabelle ;

Leveille, Emmanuella ;

Vasile, Manuela ;

Kasbi, Florence ;

Madhi, Fouad ;

Fourmaux, Christine ;

Biscardi, Sandra ;

Gluckman, Eliane ;

Socie, Gerard ;

Dalle, Jean-Hugues ;

Epaud, Ralph ;

Pondarre, Corinne .

BLOOD, 2016, 127 (14) :1814-1822

[6] Influence of sickle cell disease and treatment with hydroxyurea on sperm parameters and fertility of human males [J].

Berthaut, Isabelle ;

Guignedoux, Geoffroy ;

Kirsch-Noir, Frederique ;

de Larouziere, Vanina ;

Ravel, Celia ;

Bachir, Dora ;

Galacteros, Frederic ;

Ancel, Pierre-Yves ;

Kunstmann, Jean-Marie ;

Levy, Laurence ;

Jouannet, Pierre ;

Girot, Robert ;

Mandelbaum, Jacqueline .

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2008, 93 (07) :988-993

[7] Age-related treatment patterns in sickle cell disease patients and the associated sickle cell complications and healthcare costs [J].

Blinder, Morey A. ;

Vekeman, Francis ;

Sasane, Medha ;

Trahey, Alex ;

Paley, Carole ;

Duh, Mei Sheng .

PEDIATRIC BLOOD & CANCER, 2013, 60 (05) :828-835

[8] HLA-haploidentical bone marrow transplantation with posttransplant cyclophosphamide expands the donor pool for patients with sickle cell disease [J].

Bolanos-Meade, Javier ;

Fuchs, Ephraim J. ;

Luznik, Leo ;

Lanzkron, Sophie M. ;

Gamper, Christopher J. ;

Jones, Richard J. ;

Brodsky, Robert A. .

BLOOD, 2012, 120 (22) :4285-4291

[9] Iron-Chelating Therapy for Transfusional Iron Overload [J].

Brittenham, Gary M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (02) :146-156

[10] HEPATIC IRON STORES AND PLASMA FERRITIN CONCENTRATION IN PATIENTS WITH SICKLE-CELL-ANEMIA AND THALASSEMIA MAJOR [J].

BRITTENHAM, GM ;

COHEN, AR ;

MCLAREN, CE ;

MARTIN, MB ;

GRIFFITH, PM ;

NIENHUIS, AW ;

YOUNG, NS ;

ALLEN, CJ ;

FARRELL, DE ;

HARRIS, JW .

AMERICAN JOURNAL OF HEMATOLOGY, 1993, 42 (01) :81-85

← 1 2 3 4 5 6 7 8 9 10 →