Is Cross-Reactive Immunity Triggering COVID-19 Immunopathogenesis?

被引：43

作者：

Beretta, Alberto ^{[1
]}

Cranage, Martin ^{[2
]}

Zipeto, Donato ^{[3
]}

机构：

[1] Solongev Res, Milan, Italy

[2] St Georges Univ London, Inst Infect & Immun, London, England

[3] Univ Verona, Dept Neurosci Biomed & Movement Sci, Lab Mol Biol & Virol, Verona, Italy

来源：

FRONTIERS IN IMMUNOLOGY | 2020年 / 11卷

关键词：

COVID-19; SARS-CoV-2; antibody-dependent enhancement; immunopathogenesis; cross-reactivity; human coronaviruses; RESPIRATORY SYNDROME CORONAVIRUS; ANTIBODY-DEPENDENT ENHANCEMENT; PERITONITIS VIRUS-INFECTION; SARS CORONAVIRUS; PROTECTIVE IMMUNITY; RESPONSES; MACROPHAGES; DISEASE; NEUTRALIZATION; IMMUNIZATION;

D O I：

10.3389/fimmu.2020.567710

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The serological responses to both SARS-CoV-1 and SARS-CoV-2 virus have some unique characteristics that suggest cross-reactive priming by other human coronaviruses (hCoVs). The early kinetics and magnitude of these responses are, in some cases, associated with worse clinical outcomes in SARS and COVID-19. Cross-reactive hCoV antibody responses have been detected in both SARS and COVID-19 patients. There is also evidence that pre-existing T cell immunity to common cold coronaviruses can prime the response to SARS-CoV-2. Studies in non-human primates show that SARS-CoV-1 S-protein vaccine-induced antibodies are associated with acute lung injury in macaques challenged with SARS-CoV-1. Here we discuss the potential of cross-reactive immunity to drive the immunopathogenesis of COVID-19 and its implications for current efforts to develop immune-based therapies and vaccines.

引用

页数：9

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