Effects of medial prefrontal cortex lesions on anxiety-like behaviour in restrained and non-restrained rats

被引：19

作者：

Blanco, Eduardo ^{[1
]}

Castilla-Ortega, Estela ^{[1
]}

Miranda, Ruben ^{[2
]}

Begega, Azucena ^{[3
]}

Aguirre, Jose A. ^{[4
]}

Arias, Jorge L. ^{[3
]}

Santin, Luis J. ^{[1
]}

机构：

[1] Univ Malaga, Dept Psicobiol & Metodol CC, Fac Psicol, E-29071 Malaga, Spain

[2] Univ Islas Baleares, Dept Psicol, Fac Psicol, Palma de Mallorca 07122, Spain

[3] Univ Oviedo, Dept Psicol, Fac Psicol, Oviedo 33003, Spain

[4] Univ Malaga, Dept Fisiol Humana, Fac Med, E-29071 Malaga, Spain

来源：

BEHAVIOURAL BRAIN RESEARCH | 2009年 / 201卷 / 02期

关键词：

Stress; Frontal cortex; Elevated T-maze; Anxiety; Restraint; Rodent; ELEVATED T-MAZE; 5-HT1A RECEPTOR ACTIVATION; ANTERIOR CINGULATE CORTEX; LEARNED HELPLESSNESS; NORADRENERGIC NEURONS; RAPHE NUCLEI; C-FOS; STRESS; FEAR; MEMORY;

D O I：

10.1016/j.bbr.2009.03.001

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The medial prefrontal cortex has been associated with fear, anxiety and stress regulation, and has recently been suggested to play a crucial role in the development of behavioural changes in response to stress. In this study, we evaluated medial prefrontal cortex (mPFC) involvement in both anxiety-like behaviour and increased anxiety-like responses induced by uncontrollable restraint. Rats with mPFC electrolytic lesions (n = 7) and sham-lesioned (n = 8) were tested in the elevated T-maze (ETM). Restrained rats with mPFC lesions (n = 8) and sham-lesioned rats (n = 6) were tested in the elevated T-maze 24 h after restraint. Both two-trial passive avoidance and one-trial escape behaviours; were assessed. The results revealed that mPFC lesions impair passive avoidance, but not escape behaviour. in addition, decreased anxiety-like behaviour in both passive avoidance and escape behaviours were observed in restrained rats with mPFC lesions. Our results suggest that mPFC is important in mediating both anxiety-like behaviour expression and long-term anxiogenic-like effects induced by acute restraint. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：338 / 342

页数：5

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