Enclosed chiral environments from self-assembled metal-organic polyhedra

yEnclosed chiral spaces can be achieved using self-assembled metal-organic polyhedra. Such spaces can be useful for the recognition of chiral guests and the promotion of enantioselective reactions. Here, we provide a review of recent progress in the design, synthesis, and characterization of chiral self-assembled metal-organic polyhedra, with a particular focus on symmetry and structure. Chirality may be incorporated into molecular polyhedra prior to or during the self-assembly process. Examples of both approaches are discussed.