Effects of chronic desipramine pretreatment on open field-induced suppression of blood natural killer cell activity and cytokine response depend on the rat's behavioral characteristics

被引：10

作者：

Wrona, Dahuta ^{[1
]}

Listowska, Magdalena ^{[1
]}

Kubera, Marta ^{[2
]}

Glac, Wojciech ^{[1
]}

Grembecka, Beata ^{[1
]}

Plucinska, Karolina ^{[1
]}

Majkutewicz, Irena ^{[1
]}

Podlacha, Magdalena ^{[1
]}

机构：

[1] Univ Gdansk, Fac Biol, Dept Anim & Human Physiol, PL-80308 Gdansk, Poland

[2] Polish Acad Sci, Inst Pharmacol, Dept Expt Neuroendocrinol, PL-31343 Krakow, Poland

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2014年 / 268卷 / 1-2期

关键词：

Desipramine; Open field; Natural killer cells; Response to novelty; Social position; Plasma cytokines; NOVELTY-SEEKING BEHAVIOR; CHRONIC STRESS EXPOSURE; INDIVIDUAL-DIFFERENCES; IMMUNE ACTIVATION; MAJOR DEPRESSION; C57BL/6; MICE; CORTICOSTERONE SECRETION; NUCLEUS-ACCUMBENS; INTERFERON-GAMMA; SOCIAL POSITION;

D O I：

10.1016/j.jneuroim.2013.10.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Effects of 14 consecutive day exposure to desipramine (10 mg/kg i.p.), by itself or following chronic open field (OF) exposure, on subsequent neuroimmunological effects of acute (30 min) OF stress and the involvement of individual differences in response to novelty or social position in the anti-depressive responsiveness were investigated. Chronic desipramine pretreatment did not protect against OF stress-induced suppression of blood anti-tumor natural killer cell activity but increased plasma interleukin-10 and decreased interferon-gamma and corticosterone concentration. These effects were particularly dangerous for the animals with increased responsivity to stress (desipramine alone) or with low behavioral activity (desipramine after chronic stress). (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：13 / 24

页数：12

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