Inflammatory myopathy associated with statins: report of three cases

被引：6

作者：

Kuncova, Klara ^{[1
,2
]}

Sedlackova, Marie ^{[3
]}

Vencovsky, Jiri ^{[4
]}

Mann, Herman ^{[4
]}

Tomcik, Michal ^{[4
]}

Wenchich, Laszlo ^{[5
]}

Zamecnik, Josef ^{[1
,2
]}

机构：

[1] Charles Univ Prague, Fac Med 2, Dept Pathol & Mol Med, Prague 15006 5, Czech Republic

[2] Charles Univ Prague, Univ Hosp Motol, Prague 15006 5, Czech Republic

[3] Thomayer Hosp, Dept Rheumatol & Rehabil, Prague 4, Czech Republic

[4] Charles Univ Prague, Fac Med 1, Inst Rheumatol, Dept Rheumatol, Prague 2, Czech Republic

[5] Charles Univ Prague, Fac Med 1, Dept Pediat, Prague 2, Czech Republic

来源：

MODERN RHEUMATOLOGY | 2014年 / 24卷 / 02期

关键词：

Drug-induced myopathy; Muscle biopsy; Inflammatory myopathy; Statins; COA REDUCTASE INHIBITORS; MEDIATED NECROTIZING MYOPATHY; RETICULUM STRESS-RESPONSE; INDUCED DERMATOMYOSITIS; AUTOIMMUNE MYOSITIS; POLYMYOSITIS; SIMVASTATIN; ACTIVATION; MUTATIONS; THERAPY;

D O I：

10.3109/14397595.2013.852848

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Statins are well-established lipid-lowering drugs that reduce morbidity and mortality due to cardiovascular disease and cause adverse effects relatively rarely. It is still unclear whether statins are capable of inducing an immune-mediated response directed against skeletal muscle. Here, we present the cases of three patients who developed inflammatory myopathy in the course of statin treatment. Moreover, multiple mitochondrial DNA deletions were found in two of them. The ability of statins to induce an immune-mediated response and their interactions with mitochondrial metabolism pathways are discussed.

引用

页码：366 / 371

页数：6

共 44 条

[1]

Ahmad A, 2000, Tenn Med, V93, P21

[2]

[Anonymous], 2004, DRUGS, V64, P1181

[3] POLYMYOSITIS AND DERMATOMYOSITIS .2. [J].

BOHAN, A ;

PETER, JB .

NEW ENGLAND JOURNAL OF MEDICINE, 1975, 292 (08) :403-407

[4] POLYMYOSITIS AND DERMATOMYOSITIS .1. [J].

BOHAN, A ;

PETER, JB .

NEW ENGLAND JOURNAL OF MEDICINE, 1975, 292 (07) :344-347

[5] Effect of coenzyme Q10 on myopathic symptoms in patients treated with statins [J].

Caso, Giuseppe ;

Kelly, Patricia ;

McNurlan, Margaret A. ;

Lawson, William E. .

AMERICAN JOURNAL OF CARDIOLOGY, 2007, 99 (10) :1409-1412

[6] A Novel Autoantibody Recognizing 200-kd and 100-kd Proteins Is Associated With an Immune-Mediated Necrotizing Myopathy [J].

Christopher-Stine, Lisa ;

Casciola-Rosen, Livia A. ;

Hong, Grace ;

Chung, Tae ;

Corse, Andrea M. ;

Mammen, Andrew L. .

ARTHRITIS AND RHEUMATISM, 2010, 62 (09) :2757-2766

[7] Toxic and drug-induced myopathies [J].

Dalakas, M. C. .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2009, 80 (08) :832-838

[8] Polymyositis induced or associated with lipid-lowering drugs - Five cases [J].

Fauchais, AL ;

Ba, JI ;

Maurage, P ;

Kyndt, X ;

Bataille, D ;

Hachulla, E ;

Parent, D ;

Queyrel, V ;

Lambert, M ;

Pasturel, UM ;

Hatron, PY ;

Vanhille, P ;

Devulder, B .

REVUE DE MEDECINE INTERNE, 2004, 25 (04) :294-298

[9] A case of atorvastatin combined toxic myopathy and inflammatory myositis [J].

Folzenlogen, D .

JCR-JOURNAL OF CLINICAL RHEUMATOLOGY, 2001, 7 (05) :340-345

[10] The impact of mitochondrial tRNA mutations on the amount of ATP synthase differs in the brain compared to other tissues [J].

Fornuskova, Daniela ;

Brantova, Olga ;

Tesarova, Marketa ;

Stiburek, Lukas ;

Honzik, Tomas ;

Wenchich, Laszlo ;

Tietzeova, Evzenie ;

Hansikova, Hana ;

Zeman, Jiri .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2008, 1782 (05) :317-325

← 1 2 3 4 5 →