Comparison of published guidelines for management of coagulopathy and thrombosis in critically ill patients with COVID 19: implications for clinical practice and future investigations

被引：70

作者：

Flaczyk, Adam ^{[1
]}

Rosovsky, Rachel P. ^{[2
]}

Reed, Clay T. ^{[3
]}

Bankhead-Kendall, Brittany K. ^{[4
]}

Bittner, Edward A. ^{[1
]}

Chang, Marvin G. ^{[5
]}

机构：

[1] Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, Div Crit Care, Boston, MA 02114 USA

[2] Massachusetts Gen Hosp, Div Hematol & Oncol, 55 Fruit St, Boston, MA 02114 USA

[3] NIH, Div Hematol & Oncol, Bldg 10, Bethesda, MD 20892 USA

[4] Massachusetts Gen Hosp, Dept Surg, Div Trauma Emergency Surg & Surg Crit Care, Boston, MA 02114 USA

[5] Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, Div Cardiac Anesthesia & Crit Care, Boston, MA 02114 USA

来源：

CRITICAL CARE | 2020年 / 24卷 / 01期

关键词：

COVID-19; Coronavirus; Thrombosis; Anticoagulation; Venous thromboembolism; Hematologic monitoring; Therapeutic anticoagulation; PULMONARY-EMBOLISM;

D O I：

10.1186/s13054-020-03273-y

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Critically ill patients with COVID-19 are at increased risk for thrombotic complications which has led to an intense debate surrounding their anticoagulation management. In the absence of data from randomized controlled clinical trials, a number of consensus guidelines and recommendations have been published to facilitate clinical decision-making on this issue. However, substantive differences exist between these guidelines which can be difficult for clinicians. This review briefly summarizes the major societal guidelines and compares their similarities and differences. A common theme in all of the recommendations is to take an individualized approach to patient management and a call for prospective randomized clinical trials to address important anticoagulation issues in this population.

引用

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